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Hypertrophic tonsils as the SARS-CoV-2 reservoir in children: 23% of tonsil and adenoid tissue samples of children who had undergone adenotonsillectomy, were positive for the SARS-CoV-2 nucleoprotein
A discovery of the structural SARS-CoV-2 protein in situ in adenoids and palatine tonsils, in both epithelial and lymphomononuclear cells of different lymphoid compartments, suggests that the tonsils may be sites of prolonged infection, even without recent COVID-19 symptoms.
The carbohydrate ProLectin M increased viral clearance in patients with mild to severe COVID-19 by antagonizing the binding of galectin-3 to the S1 subunit of the SARS-CoV-2
The carbohydrate PL-M can reduce the viral load in Vero cells. In clinical studies with COVID-19 patients, PL-M treatment resulted in a rapid reduction of viral load and increased viral clearance, with no adverse effects.
COVID-19 vaccination increased concentrations of IgE specific for the SARS-CoV-2 receptor binding domain and IgG4
This study revealed increased IgE levels specific for the receptor binding domain (RBD) of the SARS-CoV-2 in individuals who had been immunized with the ChAdOx1, CoronaVac and mRNA BNT162b2 vaccines. Additionally, IgG4 levels detected after booster mRNA BNT162b2 vaccination, showed a moderate correlation with IgE levels.
De novo onset or exacerbation of psoriasis following the SARS-CoV-2 infection or COVID-19 vaccination
This study described a case series of 28 patients who experienced de novo onset or flares of psoriasis following infection with the SARS-CoV-2 or vaccination. All of these patients were successfully managed with anti-IL-17 or anti-IL-23 medications.
Featured Topics COVID-19/ Long COVID Syndrome
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Co-localization of SARS-CoV-2 spike protein with increased expression of vascular and autophagy markers in the placental tissue of unvaccinated women infected with SARS-CoV-2
Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)
These results demonstrated that nAChR subtypes interact with the neurotoxin-like region of the SARS-CoV-2, confirming that the α7 nAChR is a target for the SARS-CoV-2.
Elevated levels of non-inflammatory IgG4 antibodies specific for the SARS-CoV-2 spike protein were found in children aged 5 to 11 years one year after the BNT162b2 mRNA COVID-19 vaccination
This study found, for the first time in children, that levels of IgG4 antibodies specific for S1 and RBD significantly increased one year after the second vaccination compared to baseline.
Molecular similarities between antigenic sites of the SARS-CoV-2 RBD and 54 antigenic determinants of fifteen pathogens (bacteria, parasites, and viruses)
Seven antigenic sites of SARS-CoV-2 spike RBD showed molecular similarities with 54 antigenic determinants found in fifteen pathogen microorganisms, including bacteria, parasites and viruses.
Prion-like domains in the SARS-CoV-2 spike protein
Different beta-coronaviruses (β-CoVs) contain prion-like domains in the S proteins. However, SARS-CoV-2 is the only β-CoV with prion-like domains identified within the receptor-binding domain (RBD) of the S protein.
IgG4-related diseases (sialadenitis, pancreatitis, and hepatopathy) after COVID-19 vaccination
The authors from Japan presented two cases of immunoglobulin (Ig)G4-related diseases that developed after anti-SARS-CoV-2 vaccination.
Acyclovir clinically resolved or significantly improved symptoms in patients diagnosed with long COVID syndrome
Two case series studies demonstrated that four patients with long COVID improved with chronic use of acyclovir.
IL-6 receptor blocker-tocilizumab rapidly improved condition in two children with severe myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
IL-6 receptor blocker tocilizumab rapidly improved the condition in two children with severe, acute manifestations of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).
Featured Topics- Multispecialty
Education
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New Insights into Endometrial Cancer, MDPI, Basel, 2022
Diverse functions of mucosal resident memory T cells. Frontiers in Immunology, 2015.
Histamine H4 receptor: A novel drug target in immunoregulation and inflammation. Versita, London, 2013
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