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The attachment pattern, replication, and infection of the upper and lower human respiratory tract differ between the H5N1 virus of clade 2.3.4.4b, the H5N1 virus of clade 2.1.3.2 and a seasonal H3N2 virus
Currently circulating the HPAI H5N1 virus of clade 2.3.4.4b attached better to the human respiratory tract than the H5N1 virus of clade 2.1.3.2. More abundant attachment to the human respiratory tract of the H5N12022 virus was associated with its more effective replication.
Postmortem brain samples from COVID-19 convalescents who died within 4-13 months of acute infection showed an Alzheimer’s disease-like increase in hyperphosphorylated tau protein
This study found abnormal accumulation of hyperphosphorylated tau proteins in the postmortem human brain samples of hippocampus and medial entorhinal cortex within 4-13 months after acute COVID-19.
The striking molecular mimicry between SARS-CoV-2 and human EnaC-alpha decreases channel activity and may contribute to reduced reabsorption of alveolar fluid at the air-liquid interface
SARS-CoV-2 S protein may compete for the same processing protease with EnaC-alpha, a sodium permeable non-voltage-sensitive ion channel that controls fluid reabsorption at the air–liquid interface.
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De novo onset or exacerbation of psoriasis following the SARS-CoV-2 infection or COVID-19 vaccination
This study described a case series of 28 patients who experienced de novo onset or flares of psoriasis following infection with the SARS-CoV-2 or vaccination. All of these patients were successfully managed with anti-IL-17 or anti-IL-23 medications.
Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)
These results demonstrated that nAChR subtypes interact with the neurotoxin-like region of the SARS-CoV-2, confirming that the α7 nAChR is a target for the SARS-CoV-2.
Elevated levels of non-inflammatory IgG4 antibodies specific for the SARS-CoV-2 spike protein were found in children aged 5 to 11 years one year after the BNT162b2 mRNA COVID-19 vaccination
This study found, for the first time in children, that levels of IgG4 antibodies specific for S1 and RBD significantly increased one year after the second vaccination compared to baseline.
Molecular similarities between antigenic sites of the SARS-CoV-2 RBD and 54 antigenic determinants of fifteen pathogens (bacteria, parasites, and viruses)
Seven antigenic sites of SARS-CoV-2 spike RBD showed molecular similarities with 54 antigenic determinants found in fifteen pathogen microorganisms, including bacteria, parasites and viruses.
Prion-like domains in the SARS-CoV-2 spike protein
Different beta-coronaviruses (β-CoVs) contain prion-like domains in the S proteins. However, SARS-CoV-2 is the only β-CoV with prion-like domains identified within the receptor-binding domain (RBD) of the S protein.
IgG4-related diseases (sialadenitis, pancreatitis, and hepatopathy) after COVID-19 vaccination
The authors from Japan presented two cases of immunoglobulin (Ig)G4-related diseases that developed after anti-SARS-CoV-2 vaccination.
Acyclovir clinically resolved or significantly improved symptoms in patients diagnosed with long COVID syndrome
Two case series studies demonstrated that four patients with long COVID improved with chronic use of acyclovir.
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Education
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New Insights into Endometrial Cancer, MDPI, Basel, 2022
Diverse functions of mucosal resident memory T cells. Frontiers in Immunology, 2015.
Histamine H4 receptor: A novel drug target in immunoregulation and inflammation. Versita, London, 2013
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