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The attachment pattern, replication, and infection of the upper and lower human respiratory tract differ between the H5N1 virus of clade 2.3.4.4b, the H5N1 virus of clade 2.1.3.2 and a seasonal H3N2 virus

Currently circulating the HPAI H5N1 virus of clade 2.3.4.4b attached better to the human respiratory tract than the H5N1 virus of clade 2.1.3.2. More abundant attachment to the human respiratory tract of the H5N12022 virus was associated with its more effective replication.

Postmortem brain samples from COVID-19 convalescents who died within 4-13 months of acute infection showed an Alzheimer’s disease-like increase in hyperphosphorylated tau protein

This study found abnormal accumulation of hyperphosphorylated tau proteins in the postmortem human brain samples of hippocampus and medial entorhinal cortex within 4-13 months after acute COVID-19.

The striking molecular mimicry between SARS-CoV-2 and human EnaC-alpha decreases channel activity and may contribute to reduced reabsorption of alveolar fluid at the air-liquid interface

SARS-CoV-2 S protein may compete for the same processing protease with EnaC-alpha, a sodium permeable non-voltage-sensitive ion channel that controls fluid reabsorption at the air–liquid interface.

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The XEC variant of SARS-CoV-2 exhibits higher pseudovirus infectivity and immune evasion

Passive transfer of IgG from patients with long COVID induces mechanical and thermal sensitivity and impairs locomotor activity in mice

The rapid waning of serum antibodies after mRNA vaccination is due to the inability of mRNA vaccines to induce long-lived plasma cells in the bone marrow

Elevated levels of non-inflammatory IgG4 antibodies specific for the SARS-CoV-2 spike protein in children one year after vaccination with the mRNA BNT162b2 vaccine

Featured Topics COVID-19/Long COVID Syndrome

Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)

De novo onset or exacerbation of psoriasis following the SARS-CoV-2 infection or COVID-19 vaccination

Hypertrophic tonsils as the SARS-CoV-2 reservoir in children: 23% of tonsil and adenoid tissue samples of children who had undergone adenotonsillectomy, were positive for the SARS-CoV-2 nucleoprotein

IgG4-related sialadenitis, pancreatitis, and hepatopathy after COVID-19 vaccination (Case reports)

Cerebrovascular lesions and brain vascular abnormalities in children infected with the Omicron variant of SARS-CoV-2 (MRI study)

The mRNA-1273 and BNT162b2 COVID-19 vaccines induce different cardiotoxic effects and dysfunction in isolated cardiomyocytes

Positive effects of the flavonol quercetin in COVID-19 or post-COVID-19 syndrome

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De novo onset or exacerbation of psoriasis following the SARS-CoV-2 infection or COVID-19 vaccination

This study described a case series of 28 patients who experienced de novo onset or flares of psoriasis following infection with the SARS-CoV-2 or vaccination. All of these patients were successfully managed with anti-IL-17 or anti-IL-23 medications.

Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)

These results demonstrated that nAChR subtypes interact with the neurotoxin-like region of the SARS-CoV-2, confirming that the α7 nAChR is a target for the SARS-CoV-2.

Elevated levels of non-inflammatory IgG4 antibodies specific for the SARS-CoV-2 spike protein were found in children aged 5 to 11 years one year after the BNT162b2 mRNA COVID-19 vaccination

This study found, for the first time in children, that levels of IgG4 antibodies specific for S1 and RBD significantly increased one year after the second vaccination compared to baseline.

Molecular similarities between antigenic sites of the SARS-CoV-2 RBD and 54 antigenic determinants of fifteen pathogens (bacteria, parasites, and viruses)

Seven antigenic sites of SARS-CoV-2 spike RBD showed molecular similarities with 54 antigenic determinants found in fifteen pathogen microorganisms, including bacteria, parasites and viruses.

14% of Texas dairy farmworkers tested had elevated levels of neutralizing antibodies against a recombinant H5N1 virus of clade 2.3.4.4b

IL-6 receptor blocker-tocilizumab improved condition in two children with severe myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)

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The attachment pattern, replication, and infection of the upper and lower human respiratory tract differ between the H5N1 virus of clade 2.3.4.4b, the H5N1 virus of clade 2.1.3.2 and a seasonal H3N2 virus

Postmortem brain samples from COVID-19 convalescents who died within 4-13 months of acute infection showed an Alzheimer’s disease-like increase in hyperphosphorylated tau protein

The striking molecular mimicry between SARS-CoV-2 and human EnaC-alpha decreases channel activity and may contribute to reduced reabsorption of alveolar fluid at the air-liquid interface

The XEC variant of SARS-CoV-2 exhibits higher pseudovirus infectivity and immune evasion

Passive transfer of IgG from patients with long COVID induces mechanical and thermal sensitivity and impairs locomotor activity in mice

The rapid waning of serum antibodies after mRNA vaccination is due to the inability of mRNA vaccines to induce long-lived plasma cells in the bone marrow

Elevated levels of non-inflammatory IgG4 antibodies specific for the SARS-CoV-2 spike protein in children one year after vaccination with the mRNA BNT162b2 vaccine

Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)

De novo onset or exacerbation of psoriasis following the SARS-CoV-2 infection or COVID-19 vaccination

Hypertrophic tonsils as the SARS-CoV-2 reservoir in children: 23% of tonsil and adenoid tissue samples of children who had undergone adenotonsillectomy, were positive for the SARS-CoV-2 nucleoprotein

IgG4-related sialadenitis, pancreatitis, and hepatopathy after COVID-19 vaccination (Case reports)

Cerebrovascular lesions and brain vascular abnormalities in children infected with the Omicron variant of SARS-CoV-2 (MRI study)

The mRNA-1273 and BNT162b2 COVID-19 vaccines induce different cardiotoxic effects and dysfunction in isolated cardiomyocytes

Positive effects of the flavonol quercetin in COVID-19 or post-COVID-19 syndrome

De novo onset or exacerbation of psoriasis following the SARS-CoV-2 infection or COVID-19 vaccination

Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)

Elevated levels of non-inflammatory IgG4 antibodies specific for the SARS-CoV-2 spike protein were found in children aged 5 to 11 years one year after the BNT162b2 mRNA COVID-19 vaccination

Molecular similarities between antigenic sites of the SARS-CoV-2 RBD and 54 antigenic determinants of fifteen pathogens (bacteria, parasites, and viruses)

Prion-like domains in the SARS-CoV-2 spike protein

IgG4-related diseases (sialadenitis, pancreatitis, and hepatopathy) after COVID-19 vaccination

Acyclovir clinically resolved or significantly improved symptoms in patients diagnosed with long COVID syndrome

14% of Texas dairy farmworkers tested had elevated levels of neutralizing antibodies against a recombinant H5N1 virus of clade 2.3.4.4b

IL-6 receptor blocker-tocilizumab improved condition in two children with severe myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)

Brain neurons form excitatory glutamatergic synapses with metastatic cells of non-neural cancers

Certain bacterial species in colorectal cancer can resist the toxicity of 5-fluorouracil and reduce drug efficacy

Neuroplasticity of the maternal brain during pregnancy and postpartum

Structural brain changes in adolescents who had experienced childhood sexual abuse

The Mediterranean diet changed the gut microbiome and decreased the fecal calprotectin concentration in patients in remission of ulcerative colitis

16th International Congress on Systemic Lupus Erythematosus 21-24 May 2025, Toronto, Canada (LUPUS 2025)