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Orthostatic intolerance associated with decreased levels of circulating growth hormone was found in long COVID patients under 20 years of age
This study showed a high rate (38%) of standing test positivity in patients with long COVID. The ST-positive long COVID patients under 20 years of age had decreased circulating growth hormone levels.
By blocking the MAPK and NF-κB signaling pathways, pomegranate peel extract reduces inflammation and alleviates symptoms in a rat model of irritable bowel syndrome
These findings underline the potential of PPE in the treatment of intestinal diseases.
The P3 peptide of the SARS-CoV2 spike protein shares sequence homology with Staphylococcus aureus superantigens and several endogenous mammalian proteins and induces T-cell proliferation
This study identified a small peptide P3 in the S2 subunit of the SARS-CoV2 S protein with sequence homology to bacterial superantigens and the capacity to induce unexpected proliferation of T-cells.
Featured Topics COVID-19/Long COVID syndrome
Featured Topics-Multispecialty
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Genomic analyses of Staphylococcus aureus isolates show bacterial adaptation to COVID-19 selective pressure
Comparative genomic analysis of a collection of 339 S. aureus isolates from patients with bacteremia highlighted bacterial adaptation to COVID-19 selective pressure.
Postmortem brain samples from COVID-19 convalescents who died within 4-13 months of acute infection showed an Alzheimer’s disease-like increase in hyperphosphorylated tau protein
This study found abnormal accumulation of hyperphosphorylated tau proteins in the postmortem human brain samples of hippocampus and medial entorhinal cortex within 4-13 months after acute COVID-19.
Histamine receptor H1 acts as an independent receptor for SARS-CoV-2
Histamine receptor H1 acts as an independent receptor for SARS-CoV-2. Additionally, H1 directly interacts with ACE2, synergistically enhancing ACE2-dependent viral entry.
IgG4-related diseases (sialadenitis, pancreatitis, and hepatopathy) after COVID-19 vaccination
The authors from Japan presented two cases of immunoglobulin (Ig)G4-related diseases that developed after anti-SARS-CoV-2 vaccination.
SARS-CoV-2 can infect and replicate in human motor neurons differentiated from induced pluripotent stem cells
SARS-CoV-2 is able to infect and replicate in an in vitro model of human motor neurons differentiated from induced pluripotent stem cells.
Acyclovir clinically resolved or significantly improved symptoms in patients diagnosed with long COVID syndrome
Two case series studies demonstrated that four patients with long COVID improved with chronic use of acyclovir.
SARS-CoV-2 can infect and replicate in macrophages within atherosclerotic plaques in the human coronary artery wall
SARS-CoV-2 was detected and replicated in the coronary arteries sampled at autopsy of severe COVID-19 cases. The virus targeted plaque macrophages and demonstrated a stronger tropism for arterial wall lesions than for perivascular fat.
Acute disseminated encephalomyelitis (ADEM) can develop after acute SARS-CoV-2 infection or COVID-19 vaccination
A systematic review of the medical literature on cases of acute disseminated encephalomyelitis (ADEM) and acute hemorrhagic leukoencephalitis (AHLE) that occurred after severe acute SARS-CoV-2 infection or CoVID-19 vaccination.
The neurogenic cardiac injury
This review discusses the main pathophysiological mechanisms of heart-brain interaction leading to the neurogenic cardiac injury.
Education
You can download a free book on the Education Page
New Insights into Endometrial Cancer, MDPI, Basel, 2022
Diverse functions of mucosal resident memory T cells. Frontiers in Immunology, 2015.
Textbook of Plastic and Reconstructive Surgery, University College London, 2016
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