DiscoverMedNews
news and major stories from evidence-based medical research and published peer-reviewed medical studies
C-19 Resource Page (Post-COVID Condition & Post-vaccination syndrome)
Multispecialty Page
C-19 Resource Page (Acute COVID-19)
Education Page
Editor’s Choice
Latest Articles
Cytotoxic lesions of the corpus callosum in COVID-19 patients
Cytotoxic lesions of the corpus callosum (CLOCCs) are a rare clinicoradiologic syndrome characterized by transient and reversible lesions of the CC and possibly of the adjacent white matter. In this study, clinical, radiological and laboratory features of CLOCCs in eight COVID-19 patients were presented.
Spatial gene expression analysis revealed SARS-CoV-2-related inflammation in the epipharynx of patients with long COVID, suggesting the therapeutic potential of epipharyngeal abrasive therapy
These results suggest a possible link between long COVID and chronic epipharyngitis and emphasize the therapeutic potential of EAT in treating the symptoms of long COVID
The persistence of vaccine-derived S1 protein in CD16+ monocytes and an altered cytokine profile were detected up to 245 days after vaccination in SARS-CoV-2-uninfected individuals with post-COVID-19 vaccination syndrome
These findings suggest that the persistence of vaccine-derived S1 protein in CD16+ monocytes, and post-acute sequelae of COVID-19-like cytokine profile, may contribute to persistent post-COVID-19 vaccination syndrome.
A case series of 30 patients with newly diagnosed or relapsing glomerular diseases after COVID-19 mRNA vaccination
The most common glomerular disease after COVID-19 vaccination was immunoglobulin A nephropathy (IgAN). The absolute risk of glomerular diseases increased after the second or third COVID-19 mRNA vaccination.
SARS-CoV-2 spike and nucleocapsid proteins as well as HIV-GP120 protein were detected in extracellular vesicles or as free proteins in the bronchoalveolar lavage fluids from post-COVID patients up to two years after acute COVID-19 and from HIV-positive subjects on HAART therapy with undetectable blood viral load
Most spike and nucleocapsid proteins were contained in the extracellular vesicles. In contrast, most HIV-GP120 proteins were present as free proteins.
From the Post-COVID Condition/ Post-COVID-vaccination syndrome Page
Topic: Long COVID and lung function
From the Multispecialty Page
Most Read
The persistence of vaccine-derived S1 protein in CD16+ monocytes and an altered cytokine profile were detected up to 245 days after vaccination in SARS-CoV-2-uninfected individuals with post-COVID-19 vaccination syndrome
These findings suggest that the persistence of vaccine-derived S1 protein in CD16+ monocytes, and post-acute sequelae of COVID-19-like cytokine profile, may contribute to persistent post-COVID-19 vaccination syndrome.
One year after mRNA COVID-19 immunization, the young people show elevated cytokine levels, suggesting ongoing stimulation of the immune system
The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.
SARS-CoV-2 can infect and replicate in human motor neurons differentiated from induced pluripotent stem cells
SARS-CoV-2 is able to infect and replicate in an in vitro model of human motor neurons differentiated from induced pluripotent stem cells.
Acyclovir clinically resolved or significantly improved symptoms in patients diagnosed with long COVID syndrome
Two case series studies demonstrated that four patients with long COVID improved with chronic use of acyclovir.
The neurogenic cardiac injury
This review discusses the main pathophysiological mechanisms of heart-brain interaction leading to the neurogenic cardiac injury.
From the Acute COVID-19 Page
Topic: SARS-CoV-2 and the feto-placental pathology
Co-localization of the SARS-CoV-2 spike protein and increased expression of vascular and autophagy markers in the placental tissue of unvaccinated infected women
Increased expression of VEGF and the endothelial cell marker CD34 indicates alterations, disarrangements, or remodeling of normal vasculature, associated with vascular endothelial injury and endothelitis.
Neurodevelopmental disorders and microcephaly after in utero SARS-CoV-2 exposure (case reports)
Clinical findings, placental pathology, and immunohistochemical analysis strongly suggest that second-trimester maternal SARS-CoV-2 infection and placentitis triggered an inflammatory response in the fetoplacental unit that affected the fetal brain.
Maternal-fetal transmission of the delta variant of SARS-CoV-2, viral tropism for various fetal brain cells and brain gliosis (animal study)
The results showed significant level of maternal-fetal transmission of delta variant SARS-CoV-2 in later stages of mice pregnancy, and viral tropism for various fetal brain cells, like endothelial cells of blood vessels, barrier cells of the choroid plexus, neurons, and glial cells.
The SARS-CoV-2 proteins were found in the fetal brain cortical hemorrhages during early gestation
This study reported the presence of SARS-CoV-2 in fetal brain tissue, associated with cortical hemorrhages, and linked to reduced blood vessel integrity and monocyte infiltration of the hemorrhagic cortex. SARS-COV-2 antigens were also detected in the placenta, amnion, and umbilical cord during early gestation (the first and second trimesters of pregnancy).
Severe thickening and fibrosis of the vessel walls, smooth muscle cell proliferation, and lumen occlusion were found in the placental arteries of women infected with SARS-CoV-2
The results show severe vascular remodeling of placental arteries, including severe thickening of the vessel walls and the occlusion of the vessel lumen, in women with COVID-19 during pregnancy.
Stool samples from newborns, born to mothers infected with SARS-CoV-2 during pregnancy, contained SARS-CoV-2 RNA and S protein at delivery, indicating in utero viral transmission to the fetal intestine
The mechanism of in utero transmission to the fetal intestine remains unclear. Since viral RNA was detected in the placenta and amniotic fluid, this might be the pathway of viral transmission.
Education
New Insights into Endometrial Cancer, MDPI, Basel, 2022
You can download a free book at the Education Page
New Insights into Endometrial Cancer, MDPI, Basel, 2022
Diverse functions of mucosal resident memory T cells. Frontiers in Immunology, 2015.
Textbook of Plastic and Reconstructive Surgery, University College London, 2016
Conference Coverage
You can find more at the Education Page