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Cytotoxic lesions of the corpus callosum in COVID-19 patients
Cytotoxic lesions of the corpus callosum (CLOCCs) are a rare clinicoradiologic syndrome characterized by transient and reversible lesions of the CC and possibly of the adjacent white matter. In this study, clinical, radiological and laboratory features of CLOCCs in eight COVID-19 patients were presented.
Spatial gene expression analysis revealed SARS-CoV-2-related inflammation in the epipharynx of patients with long COVID, suggesting the therapeutic potential of epipharyngeal abrasive therapy
These results suggest a possible link between long COVID and chronic epipharyngitis and emphasize the therapeutic potential of EAT in treating the symptoms of long COVID
The persistence of vaccine-derived S1 protein in CD16+ monocytes and an altered cytokine profile were detected up to 245 days after vaccination in SARS-CoV-2-uninfected individuals with post-COVID-19 vaccination syndrome
These findings suggest that the persistence of vaccine-derived S1 protein in CD16+ monocytes, and post-acute sequelae of COVID-19-like cytokine profile, may contribute to persistent post-COVID-19 vaccination syndrome.
A case series of 30 patients with newly diagnosed or relapsing glomerular diseases after COVID-19 mRNA vaccination
The most common glomerular disease after COVID-19 vaccination was immunoglobulin A nephropathy (IgAN). The absolute risk of glomerular diseases increased after the second or third COVID-19 mRNA vaccination.
SARS-CoV-2 spike and nucleocapsid proteins as well as HIV-GP120 protein were detected in extracellular vesicles or as free proteins in the bronchoalveolar lavage fluids from post-COVID patients up to two years after acute COVID-19 and from HIV-positive subjects on HAART therapy with undetectable blood viral load
Most spike and nucleocapsid proteins were contained in the extracellular vesicles. In contrast, most HIV-GP120 proteins were present as free proteins.
Featured Topics COVID-19/Long COVID syndrome
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One year after mRNA COVID-19 immunization, the young people showed elevated cytokine levels, suggesting ongoing stimulation of the immune system
The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.
Immunological and other features of post-COVID-19 vaccination syndrome
This study demonstrated immunological and other characteristics in individuals experiencing persistent symptoms following COVID-19 vaccination.
New-onset or relapse of uveitis within a month after COVID-19 infection or vaccination
These studies found an association between COVID-19 infection or vaccination and newly diagnosed or recurrent uveitis.
Postmortem brain samples from COVID-19 convalescents who died within 4-13 months of acute infection showed an Alzheimer’s disease-like increase in hyperphosphorylated tau protein
This study found abnormal accumulation of hyperphosphorylated tau proteins in the postmortem human brain samples of hippocampus and medial entorhinal cortex within 4-13 months after acute COVID-19.
Passive transfer of IgG from patients with long COVID induces mechanical and thermal sensitivity and impairs locomotor activity in mice
These findings demonstrate that transfer of IgG from long COVID patients to mice replicates disease symptoms, underscoring a causative and heterogeneous role of IgG in the pathogenesis of long COVID.
The rapid waning of serum antibodies after mRNA vaccination is due to the inability of mRNA vaccines to induce long-lived plasma cells in the bone marrow
This study showed the exclusion of SARS-CoV-2 specificity from the bone marrow long-lived plasma cell (LLPC) compartment and the inability of mRNA vaccines to induce necessary precursor programs to fully mature into the bone marrow LLPC.
Featured Topics Multispecialty
New Insights into Endometrial Cancer, MDPI, Basel, 2022
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New Insights into Endometrial Cancer, MDPI, Basel, 2022
Diverse functions of mucosal resident memory T cells. Frontiers in Immunology, 2015.
Textbook of Plastic and Reconstructive Surgery, University College London, 2016
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