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The P3 peptide of the SARS-CoV2 spike protein shares sequence homology with Staphylococcus aureus superantigens and several endogenous mammalian proteins and induces T-cell proliferation

Elevated levels of arthroplasty-relevant metals were found in the blood and cerebrospinal fluid of individuals with arthroplasty implants

Phase-resolved functional lung MRI revealed pulmonary perfusion abnormalities in children and adolescents with post-COVID syndrome (84% COVID-vaccinated)

The SARS-CoV-2 spike protein impacts retinal development in retinal organoids derived from human pluripotent stem cells

This work highlights different effects of SARS-CoV-2 S protein on both early and late stages of retinal development, and provides insights into the cellular and molecular mechanisms of these effects.

Elevated levels of arthroplasty-relevant metals were found in the blood and cerebrospinal fluid of individuals with arthroplasty implants

This cross-sectional study showed that chronic exposure to arthroplasty implants was associated with increased blood levels of cobalt, chromium, titanium, niobium, and zirconium. Arthroprosthetic cobalt, chromium, titanium, niobium, and zirconium seemed to cross blood-brain barrier and accumulate in CSF.

The changes in innate and adaptive immune cells, as well as a shift from Th1 to Th2 cytokine pattern, were found in unvaccinated COVID-19 convalescents 10 months after the infection

A follow-up study of immune parameters in unvaccinated COVID-19 convalescents 10 weeks and 10 months after a first and mostly mild infection with the Wuhan-strain Hu-1 showed a long-term reduction of innate and adaptive immune cells, associated with a shift from Th1 to Th2 cytokine pattern.

Sex-specific differences in the gene transcriptomics of peripheral blood cells are observed in vaccinated patients with post-COVID syndrome

The gene expression in men with post-COVID syndrome differed from that of men who had recovered after COVID-19, with 399 differentially expressed genes (DEGs) compared to men who had recovered after COVID-19 and to control men. These DEGs showed high enrichment in genes related to erythrocyte development and differentiation and heme metabolism.

Recurrent venous thromboembolism in patients who discontinued anticoagulant therapy for COVID-19-associated venous thromboembolism after at least three months of treatment

After discontinuation of anticoagulation therapy, recurrent VTE occurred in 3.5% of patients, with a rate of 3.1 per 100 patient-years, and no fatal pulmonary embolism.

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Featured Topics COVID-19/Long COVID syndrome

A Korean nationwide study conducted on more than 44 million vaccinated individuals found that the incidence of myocarditis associated with COVID vaccination was highest in males aged 12 to 17 years, and the most serious adverse effect was sudden cardiac death

Recurrent venous thromboembolism in patients who discontinued anticoagulant therapy for COVID-19-associated venous thromboembolism after at least three months of treatment

Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)

Immunological and other features of post-COVID-19 vaccination syndrome

This study demonstrated immunological and other characteristics in individuals experiencing persistent symptoms following COVID-19 vaccination.

New-onset or relapse of uveitis within a month after COVID-19 infection or vaccination

These studies found an association between COVID-19 infection or vaccination and newly diagnosed or recurrent uveitis.

Passive transfer of IgG from patients with long COVID induces mechanical and thermal sensitivity and impairs locomotor activity in mice

These findings demonstrate that transfer of IgG from long COVID patients to mice replicates disease symptoms, underscoring a causative and heterogeneous role of IgG in the pathogenesis of long COVID.

The rapid waning of serum antibodies after mRNA vaccination is due to the inability of mRNA vaccines to induce long-lived plasma cells in the bone marrow

This study showed the exclusion of SARS-CoV-2 specificity from the bone marrow long-lived plasma cell (LLPC) compartment and the inability of mRNA vaccines to induce necessary precursor programs to fully mature into the bone marrow LLPC.

IgG4-related diseases (sialadenitis, pancreatitis, and hepatopathy) after COVID-19 vaccination

Two cases of immunoglobulin (Ig)G4-related diseases that developed after COVID vaccination.

SARS-CoV-2 can infect and replicate in human motor neurons differentiated from induced pluripotent stem cells

SARS-CoV-2 is able to infect and replicate in an in vitro model of human motor neurons differentiated from induced pluripotent stem cells.

Featured Topics Multispecialty

According to a nationwide Swedish study, the use of antidepressants is associated with faster cognitive deterioration in patients with dementia

In a 7-year follow-up, 61% of patients diagnosed with type 2 diabetes who had no cardiovascular disease were found to have subclinical left ventricular dysfunction

In patients with newly diagnosed multiple sclerosis, an altered IgA-bound fecal microbiota and an altered abundance and prevalence of specific gut bacterial strains were found before and after B-cell depletion therapy

New Insights into Endometrial Cancer, MDPI, Basel, 2022

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New Insights into Endometrial Cancer, MDPI, Basel, 2022

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Diverse functions of mucosal resident memory T cells. Frontiers in Immunology, 2015.

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Textbook of Plastic and Reconstructive Surgery, University College London, 2016