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The SARS-CoV-2 spike protein acts as an allosteric agonist of β-adrenergic receptors (a possible mechanism underlying cardiovascular symptoms in long-COVID patients)
SARS-CoV-2 spike protein activates human cardiac fibroblasts and promotes cardiac fibrosis
The S1 protein activates human CFs by priming NLRP3 inflammasomes through NF-κB signaling in an ACE2-dependent way.
Co-localization of SARS-CoV-2 spike protein with increased expression of vascular and autophagy markers in the placental tissue of unvaccinated women infected with SARS-CoV-2
Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)
These results demonstrated that nAChR subtypes interact with the neurotoxin-like region of the SARS-CoV-2, confirming that the α7 nAChR is a target for the SARS-CoV-2.
Featured Topics COVID-19/ Long COVID Syndrome
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Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)
These results demonstrated that nAChR subtypes interact with the neurotoxin-like region of the SARS-CoV-2, confirming that the α7 nAChR is a target for the SARS-CoV-2.
Elevated levels of non-inflammatory IgG4 antibodies specific for the SARS-CoV-2 spike protein in children one year after vaccination with the mRNA BNT162b2
This study found, for the first time in children, that levels of IgG4 antibodies specific for S1 and RBD significantly increased one year after the second vaccination compared to baseline.
Molecular similarities between antigenic sites of the SARS-CoV-2 RBD and 54 antigenic determinants of fifteen pathogens (bacteria, parasites, and viruses)
Seven antigenic sites of SARS-CoV-2 spike RBD showed molecular similarities with 54 antigenic determinants found in fifteen pathogen microorganisms, including bacteria, parasites and viruses.
Brain functional connectome in individuals with primarily neurological symptoms of post-COVID syndrome
These findings demonstrate characteristics and changes of the complex network known as brain functional connectome in individuals with primarily neurological symptoms of post-COVID syndrome.
Prion-like domains in the SARS-CoV-2 spike protein
Different beta-coronaviruses (β-CoVs) contain prion-like domains in the S proteins. However, SARS-CoV-2 is the only β-CoV with prion-like domains identified within the receptor-binding domain (RBD) of the S protein.
IgG4-related diseases (sialadenitis, pancreatitis, and hepatopathy) after COVID-19 vaccination
The authors from Japan presented two cases of immunoglobulin (Ig)G4-related diseases that developed after anti-SARS-CoV-2 vaccination.
Acyclovir clinically resolved or significantly improved symptoms in patients diagnosed with long COVID (case series studies)
Two case series studies demonstrated that four patients with long COVID improved with chronic use of acyclovir.
IL-6 receptor blocker-tocilizumab improved condition in two children with severe myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
IL-6 receptor blocker tocilizumab rapidly improved the condition in two children with severe, acute manifestations of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).
Featured Topics- Multispecialty
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