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Intussusceptive angiogenesis could be the main driver for a specific cardiac injury induced by SARS-CoV-2
The most remarkable finding in the cardiac remodeling triggered by the SARS-CoV-2 infection was a marked neovascularization in the form of intussusceptive angiogenesis, which was associated with a significant infiltration of CD11b+/TIE2+ macrophages, which are drivers of intussusceptive angiogenesis.
Azithromycin is superior to other macrolides in improving the respiratory epithelial barrier in vitro
Azithromycin treatment was distinct in terms of enhancement of the epithelial barrier, retention of phospholipids, vesicle build-up, and its effect on gene sets related to keratinocyte differentiation and establishment of skin barrier.
One year after mRNA COVID-19 immunization, the young people showed elevated cytokine levels, suggesting ongoing stimulation of the immune system
The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.
The SARS-CoV-2 spike protein impacts retinal development in retinal organoids derived from human pluripotent stem cells
This work highlights different effects of SARS-CoV-2 S protein on both early and late stages of retinal development, and provides insights into the cellular and molecular mechanisms of these effects.
Elevated levels of arthroplasty-relevant metals were found in the blood and cerebrospinal fluid of individuals with arthroplasty implants
This cross-sectional study showed that chronic exposure to arthroplasty implants was associated with increased blood levels of cobalt, chromium, titanium, niobium, and zirconium. Arthroprosthetic cobalt, chromium, titanium, niobium, and zirconium seemed to cross blood-brain barrier and accumulate in CSF.
Featured Topics COVID-19/Long COVID syndrome
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One year after mRNA COVID-19 immunization, the young people showed elevated cytokine levels, suggesting ongoing stimulation of the immune system
The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.
Immunological and other features of post-COVID-19 vaccination syndrome
This study demonstrated immunological and other characteristics in individuals experiencing persistent symptoms following COVID-19 vaccination.
New-onset or relapse of uveitis within a month after COVID-19 infection or vaccination
These studies found an association between COVID-19 infection or vaccination and newly diagnosed or recurrent uveitis.
Postmortem brain samples from COVID-19 convalescents who died within 4-13 months of acute infection showed an Alzheimer’s disease-like increase in hyperphosphorylated tau protein
This study found abnormal accumulation of hyperphosphorylated tau proteins in the postmortem human brain samples of hippocampus and medial entorhinal cortex within 4-13 months after acute COVID-19.
Passive transfer of IgG from patients with long COVID induces mechanical and thermal sensitivity and impairs locomotor activity in mice
These findings demonstrate that transfer of IgG from long COVID patients to mice replicates disease symptoms, underscoring a causative and heterogeneous role of IgG in the pathogenesis of long COVID.
The rapid waning of serum antibodies after mRNA vaccination is due to the inability of mRNA vaccines to induce long-lived plasma cells in the bone marrow
This study showed the exclusion of SARS-CoV-2 specificity from the bone marrow long-lived plasma cell (LLPC) compartment and the inability of mRNA vaccines to induce necessary precursor programs to fully mature into the bone marrow LLPC.
Featured Topics Multispecialty
New Insights into Endometrial Cancer, MDPI, Basel, 2022
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New Insights into Endometrial Cancer, MDPI, Basel, 2022
Diverse functions of mucosal resident memory T cells. Frontiers in Immunology, 2015.
Textbook of Plastic and Reconstructive Surgery, University College London, 2016
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