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The P3 peptide of the SARS-CoV2 spike protein shares sequence homology with Staphylococcus aureus superantigens and several endogenous mammalian proteins and induces T-cell proliferation

Individuals with neuro-post-COVID syndrome and poorer cognitive performance have a distinct immunological signature (a reduced functionality of CD8+ TEM cells correlates with high depression scores)

Brain neurons form excitatory glutamatergic synapses with metastatic cells of non-neural cancers, mediated by AMPA glutamate receptors, with metastatic cancer cells on the postsynaptic side of the synapses

SARS-CoV-2 in vitro triggers the inflammation and senescence pathways in A9 dopaminergic neurons (mostly affected by Parkinson’s disease in the substantia nigra) derived from human pluripotent stem cells. Increased risk of viral-induced parkinsonism?

Quantitative susceptibility mapping revealed microstructural abnormalities in several medullary clusters associated with respiratory function and body homeostasis in COVID-19 survivors over months after hospitalization

Elevated levels of arthroplasty-relevant metals were found in the blood and cerebrospinal fluid of individuals with arthroplasty implants

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New Insights into Endometrial Cancer, MDPI, Basel, 2022

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The persistence of vaccine-derived S1 protein in CD16+ monocytes and post-acute sequelae of COVID-19 (PASC)-like cytokine profile up to 245 days after vaccination may contribute to post-COVID vaccination syndrome in SARS-CoV-2-uninfected individuals

These findings suggest that the persistence of vaccine-derived S1 protein in CD16+ monocytes, and post-acute sequelae of COVID-19-like cytokine profile, may contribute to persistent post-COVID-19 vaccination syndrome.

One year after mRNA COVID-19 immunization, the young people show elevated cytokine levels, suggesting ongoing stimulation of the immune system

The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.

SARS-CoV-2 infection in vitro triggered the inflammation and senescence pathways in A9 dopaminergic neurons (mostly affected by Parkinson’s disease in the substantia nigra) derived from human pluripotent stem cells. Increased risk of viral-induced parkinsonism?

This study demonstrated selective in vitro vulnerability of A9 DA neurons derived from human pluripotent stem cells to SARS-CoV-2 infection and the associated inflammatory and cellular senescence response.

SARS-CoV-2 can infect and replicate in human motor neurons differentiated from induced pluripotent stem cells

SARS-CoV-2 is able to infect and replicate in an in vitro model of human motor neurons differentiated from induced pluripotent stem cells.

Acyclovir clinically resolved or significantly improved symptoms in patients diagnosed with long COVID syndrome

Two case series studies demonstrated that four patients with long COVID improved with chronic use of acyclovir.

Selected Topics

Post-COVID Condition/ Post-COVID-vaccination syndrome & Cognitive Impairment

SARS-CoV-2 & Cardiac Tissue

outcomes of sports-related brain concussion

Sex/Gender in human medicine

Post-COVID Condition/ Post-COVID-vaccination syndrome and Reactivation of Latent Viruses

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