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The P3 peptide of the SARS-CoV2 spike protein shares sequence homology with Staphylococcus aureus superantigens and several endogenous mammalian proteins and induces T-cell proliferation

Elevated levels of arthroplasty-relevant metals were found in the blood and cerebrospinal fluid of individuals with arthroplasty implants

Phase-resolved functional lung MRI revealed pulmonary perfusion abnormalities in children and adolescents with post-COVID syndrome (84% COVID-vaccinated)

Intussusceptive angiogenesis could be the main driver for a specific cardiac injury induced by SARS-CoV-2

The most remarkable finding in the cardiac remodeling triggered by the SARS-CoV-2 infection was a marked neovascularization in the form of intussusceptive angiogenesis, which was associated with a significant infiltration of CD11b+/TIE2+ macrophages, which are drivers of intussusceptive angiogenesis.

Azithromycin is superior to other macrolides in improving the respiratory epithelial barrier in vitro

Azithromycin treatment was distinct in terms of enhancement of the epithelial barrier, retention of phospholipids, vesicle build-up, and its effect on gene sets related to keratinocyte differentiation and establishment of skin barrier.

One year after mRNA COVID-19 immunization, the young people showed elevated cytokine levels, suggesting ongoing stimulation of the immune system

The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.

The SARS-CoV-2 spike protein impacts retinal development in retinal organoids derived from human pluripotent stem cells

This work highlights different effects of SARS-CoV-2 S protein on both early and late stages of retinal development, and provides insights into the cellular and molecular mechanisms of these effects.

Elevated levels of arthroplasty-relevant metals were found in the blood and cerebrospinal fluid of individuals with arthroplasty implants

This cross-sectional study showed that chronic exposure to arthroplasty implants was associated with increased blood levels of cobalt, chromium, titanium, niobium, and zirconium. Arthroprosthetic cobalt, chromium, titanium, niobium, and zirconium seemed to cross blood-brain barrier and accumulate in CSF.

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Featured Topics COVID-19/Long COVID syndrome

A Korean nationwide study conducted on more than 44 million vaccinated individuals found that the incidence of myocarditis associated with COVID vaccination was highest in males aged 12 to 17 years, and the most serious adverse effect was sudden cardiac death

Recurrent venous thromboembolism in patients who discontinued anticoagulant therapy for COVID-19-associated venous thromboembolism after at least three months of treatment

Modulation of the α7 nicotinic acetylcholine receptor by the “neurotoxin-like region” of the SARS-CoV-2 spike protein is selective, allosteric, and concentration-specific (a role in aggression and anxiety?)

One year after mRNA COVID-19 immunization, the young people showed elevated cytokine levels, suggesting ongoing stimulation of the immune system

The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.

Immunological and other features of post-COVID-19 vaccination syndrome

This study demonstrated immunological and other characteristics in individuals experiencing persistent symptoms following COVID-19 vaccination.

New-onset or relapse of uveitis within a month after COVID-19 infection or vaccination

These studies found an association between COVID-19 infection or vaccination and newly diagnosed or recurrent uveitis.

Postmortem brain samples from COVID-19 convalescents who died within 4-13 months of acute infection showed an Alzheimer’s disease-like increase in hyperphosphorylated tau protein

This study found abnormal accumulation of hyperphosphorylated tau proteins in the postmortem human brain samples of hippocampus and medial entorhinal cortex within 4-13 months after acute COVID-19.

Passive transfer of IgG from patients with long COVID induces mechanical and thermal sensitivity and impairs locomotor activity in mice

These findings demonstrate that transfer of IgG from long COVID patients to mice replicates disease symptoms, underscoring a causative and heterogeneous role of IgG in the pathogenesis of long COVID.

The rapid waning of serum antibodies after mRNA vaccination is due to the inability of mRNA vaccines to induce long-lived plasma cells in the bone marrow

This study showed the exclusion of SARS-CoV-2 specificity from the bone marrow long-lived plasma cell (LLPC) compartment and the inability of mRNA vaccines to induce necessary precursor programs to fully mature into the bone marrow LLPC.

Featured Topics Multispecialty

According to a nationwide Swedish study, the use of antidepressants is associated with faster cognitive deterioration in patients with dementia

In a 7-year follow-up, 61% of patients diagnosed with type 2 diabetes who had no cardiovascular disease were found to have subclinical left ventricular dysfunction

In patients with newly diagnosed multiple sclerosis, an altered IgA-bound fecal microbiota and an altered abundance and prevalence of specific gut bacterial strains were found before and after B-cell depletion therapy

New Insights into Endometrial Cancer, MDPI, Basel, 2022

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New Insights into Endometrial Cancer, MDPI, Basel, 2022

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Diverse functions of mucosal resident memory T cells. Frontiers in Immunology, 2015.

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Textbook of Plastic and Reconstructive Surgery, University College London, 2016