This retrospective study of 4,520 pediatric patients infected with the Omicron variant of SARS-CoV-2 demonstrated that acute necrotizing encephalopathy and pneumonia with comorbidities were the main causes of death.
Acute COVID-19, Long COVID, Post COVID-vaccination syndrome & Children/Adolescents-Neurology
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Cerebrovascular lesions and brain vascular abnormalities in children infected with the Omicron variant of SARS-CoV-2 (MRI study)
This study has shown cerebrovascular lesions and vascular abnormalities in a high proportion (48.4%) of children with severe neurological manifestations of infection with the Omicron variant of SARS-CoV-2.
Neurodevelopmental disorders and microcephaly after in utero SARS-CoV-2 exposure (case reports)
Clinical findings, placental pathology, and immunohistochemical analysis strongly suggest that second-trimester maternal SARS-CoV-2 infection and placentitis triggered an inflammatory response in the fetoplacental unit that affected the fetal brain.
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Acute encephalopathy in unvaccinated children infected with the Omicron variant of SARS-CoV-2 (Japanese nationwide epidemiological study)
A significantly higher number of patients with SARS-CoV-2-associated acute encephalopathy experienced severe disability or even death than patients with acute encephalopathy not associated with SARS-CoV-2.
The SARS-CoV-2 proteins were found in the fetal brain cortical hemorrhages during early gestation
This study reported the presence of SARS-CoV-2 in fetal brain tissue, associated with cortical hemorrhages, and linked to reduced blood vessel integrity and monocyte infiltration of the hemorrhagic cortex. SARS-COV-2 antigens were also detected in the placenta, amnion, and umbilical cord during early gestation (the first and second trimesters of pregnancy).
Neurodevelopmental sequelae in fetuses exposed to maternal SARS-CoV-2 infection may be gender-specific
This study demonstrated that the risk of neurodevelopmental sequelae in fetuses exposed to maternal SARS-CoV-2 infection was gender-specific.
Pediatric patients with the Omicron variant of SARS-CoV-2 have a higher rate of simple or complex febrile seizures compared to children infected with non-Omicron variants
The Omicron variant of SARS-CoV-2 was associated with a higher rate of febrile seizures and unconsciousness in infected children compared to non-Omicron variants.
