AHA presidental advisory provides the definition of cardiovascular-kidney-metabolic syndrome syndrome and the guidance on how to better detect, prevent, and manage it.
Diseases & Drugs
This review article discusses the new perspective of glaucoma as a tau-associated disorder, and analyzes the recent findings on the link between tau protein dysregulation and glaucomatous neurodegeneration.
The risk of cardiac arrhythmias is increased in patients with inflammatory bowel disease (nationwide Swedish cohort study)
The patients with inflammatory bowel disease had an increased long-term risk of developing cardiac arrhythmias, with the exception of bradyarrhythmias
Anti-SARS-CoV-2 antibodies can cross-react with Dengue virus and enhance its infection through antibody-dependent enhancement
Anti-SARS-CoV-2 antibodies can cross-react with DENV-2 and enhance Dengue virus infection through antibody-dependent enhancement (ADE).
Transfer of fecal material from Alzheimer’s disease patients to healthy young adult rats resulted in cognitive symptoms and impaired adult hippocampal neurogenesis
Transfer of fecal material from Alzheimer’s disease patients to healthy young adult rats resulted in cognitive symptoms and impaired hippocampal neurogenesis.
Antiviral drugs have unrecognized antibacterial properties that may contribute to antibiotic resistance burden
A culture-based study, using the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Bacillus cereus, has shown that antiviral drugs have previously unrecognized antibacterial properties that may contribute to antibiotic resistance burden.
Semorinemab, an anti-tau monoclonal antibody, did not improve functional and global outcomes in patients with mild-to-moderate Alzheimer’s disease (the phase II Lauriet study)
Results showed that semorinemab had a modest positive cognitive effect in patients with mild to moderate AD, but, did not result in improved functional or global outcomes.
In a recent case report, the authors from the US have warned about an increase in the incidence of leprosy cases without traditional risk factors in Florida, and rising evidence that leprosy has become endemic in the southeastern United States.
The WHO recently confirmed a Middle East respiratory syndrome (MERS) case in the United Arab Emirates-case description (from July 24, 2023)
On July 24, 2023, the World Health Organization announced a case of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the United Arab Emirates.
A disruption in the expression of steroid receptor coactivator 3 on the regulatory T cells led to the complete elimination of tumors in mouse models of cancer
The findings showed that SRC-3 is a key modulator of Tregs–mediated tumor escape. A disruption in the expression of SRC-3 in Tregs resulted in a complete elimination of tumors in aggressive syngeneic breast cancer mouse models.
A novel signaling-specific inhibitor of the CB1 receptor as a safe and potentially effective treatment for cannabis use disorder (phase 1 and phase 2a randomized trials)
AEF0117 is the first member of a novel pharmacological class of inhibitors, called CB1-SSi, that change the activity of the target receptor in a signaling-specific manner.
Treatment with antidepressants, antipsychotics, or mood stabilizers was not associated with a reduced risk of suicide in patients with borderline personality disorder (a nationwide Swedish study)
The use of ADHD medications was associated with a reduced risk of attempted or completed suicide, possibly due to diminished impulsivity. Treatment with antidepressants, antipsychotics, or mood stabilizers does not seem to reduce suicidal behavior in patients with BPD.
The Japanese researchers used nuclear medicine techniques, trans-omic analysis of blood samples, and cultured cell experiments to examine how dysautonomia in Parkinson’s disease affects the intricate connection between the thyroid gland and the liver.
Similar changes in the synaptic proteome of humans with schizophrenia or bipolar disorder and mouse model
This study revealed pronounced molecular changes in synapses purified from postmortem dorsolateral prefrontal cortex of humans with schizophrenia or bipolar disorder, and in the cerebral cortex of Akap11-deficient mice, respectively.
The radioactivity of the 14C-tyrosine was discovered in the brain after gut microbial fermentation in pigs
The radioactivity of the 14C- tyrosine was found in the brain after gut microbial fermentation. This confirms the possibility that metabolites of gut-fermented amino acid precursors to neurotransmitters such as tyrosine, may have an impact on brain functions.
The review discusses the main pathophysiological mechanisms of heart-brain interaction leading to the neurogenic cardiac injury.
A vascular graft from a combination of tropoelastin and polyglycerol sebacate mimics the structure of living blood vessels
Researchers developed a novel small-diameter vascular graft that facilitates de novo formation of a structurally appropriate elastin-containing intima-media region following implantation.
The first atlas of pan-cancer mycobiome, the collective of fungi within the microbiome, — a survey of 35 types of cancer and their associated fungi. The results showed that fungi were detected in all cancer types examined and were often intracellular.
The distribution of the microbiota within a tumor is not random, but highly organized in microniches with immune and epithelial cell functions that promote cancer progression.
A report of the third case of HIV-1 cure after allogeneic CCR5Δ32/Δ32 hematopoietic stem cell transplantation provides detailed information about the virological and immunological signature before and after analytical treatment interruption.
Persons with disabilities experience more violence in their lifetime than non-disabled persons, and are three times more likely to be sexually assaulted. Physical and sexual abuse against women with disabilities is more frequent, even about twice as common as for women without disabilities.
The findings demonstrate that RNA-sequencing of amniotic fluid cells could be implemented in a clinical setting as a complementary diagnostic tool to whole exome sequencing and whole genome sequencing, to provide functional evidence for variants affecting expression or splicing that cannot be explained by DNA sequencing.
Due to their unique physicochemical properties, nanoparticles can directly cross the placenta and cause damage to the fetus, resulting in various fetal abnormalities. Nanotoxicity at the maternal–fetal interface involves various underlying molecular mechanisms such as oxidative stress, DNA damage, apoptosis, and autophagy.
The accumulation of nanoparticles in the reproductive organs of female mice impairs the development of oocytes and can compromise fertility. In addition, cancer treatment with nanomedicines seems to be affected by the specific distribution of nanoparticles in the female reproductive system.