After discontinuation of anticoagulation therapy, recurrent VTE occurred in 3.5% of patients, with a rate of 3.1 per 100 patient-years, and no fatal pulmonary embolism.
Long COVID/Post-vaccination syndrome & Cardiovascular system
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A Korean nationwide study conducted on more than 44 million vaccinated individuals found that the incidence of myocarditis associated with COVID vaccination was highest in males aged 12 to 17 years, and the most serious adverse effect was sudden cardiac death
The authors concluded that the findings of sudden cardiac deaths attributable to COVID vaccine-related myocarditis warrant the careful monitoring or warning of sudden cardiac death as a potentially fatal complication of COVID-19 vaccination, especially in individuals younger than 45 years of age who received the mRNA vaccines.
Orthostatic intolerance associated with decreased levels of circulating growth hormone was found in long COVID patients under 20 years of age
This study showed a high rate (38%) of standing test positivity in patients with long COVID. The ST-positive long COVID patients under 20 years of age had decreased circulating growth hormone levels.
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The SARS-CoV-2 spike protein acts as an allosteric agonist of β-adrenergic receptors and contributes to sympathetic hyperactivity
This study is the first to show that the SARS-CoV-2 spike protein activates β-adrenergic receptors in cardiomyocytes, contributes to cardiac sympathetic hyperactivity and increases activation of downstream β-adrenergic receptor signaling induced by epinephrine.
SARS-CoV-2 spike protein activates human cardiac fibroblasts and promotes cardiac fibrosis
The S1 protein activates human CFs by priming NLRP3 inflammasomes through NF-κB signaling in an ACE2-dependent way.
Spontaneous dissection of the internal carotid artery in a fully vaccinated woman infected with SARS-CoV-2 (case report)
This case report describes a fully vaccinated woman positive for a non-Omicron variant of SARS-CoV-2 who experienced a spontaneous internal carotid dissection. A dissection was treated successfully with a flow-diverter stent.
Endothelial dysfunction detected after the second BNT162b2 mRNA COVID-19 vaccination was restored within six months
After the second BNT162b2 mRNA vaccination, brachial artery flow-mediated dilation assessment showed endothelial dysfunction in relatively healthy participants, which was restored within six months.
The mRNA-1273 and BNT162b2 COVID-19 vaccines induce different cardiotoxic effects and dysfunction in isolated cardiomyocytes
This study showed for the first time that mRNA-1273 and BNT162b2 COVID-19 vaccines induced cardiotoxic effects with disturbances of normal contractile function in rat cardiomyocytes. The effects of vaccines differed fundamentally in their pathophysiological mechanisms.
Higher 18F-FDG uptake was detected in the myocardium, axilla, liver, and spleen of asymptomatic vaccinated individuals up to 6 months after the second mRNA COVID-19 vaccination (PET/CT study)
Individuals who were asymptomatic and underwent PET/CT within a period of 180 days following their second vaccination had increased 18Fluorine-fluorodeoxyglucose uptake in the myocardium, axilla, liver, and spleen as compared to unvaccinated individuals.
The VAERS reporting rates of myocarditis/pericarditis after mRNA COVID-19 vaccination demonstrate a higher reporting rate mainly after the second dose, particularly among young males
In this retrospective pharmacovigilance study of safety signals associated with myocarditis/pericarditis after the primary and up to three booster doses of mRNA COVID-19 vaccines, the second dose of the vaccines showed the strongest signal in vaccinated individuals under 25 years old.
Cardiac MRI signs of non-ischemic myocardial fibrosis were found in 30% of patients diagnosed with long COVID syndrome
30% of patients diagnosed with long COVID syndrome had cardiac MRI signs of non-ischemic fibrosis, exceeding the prevalence of this disease in the normal adult population.
Extensive thrombosis of cerebral venous sinuses and similar organization of cerebral thrombi were found in all three patients who died of vaccine-induced immune thrombotic thrombocytopenia
The authors performed the immunohistological analysis of clots from three people who died from cerebral venous thrombosis (CVT) related to vaccine-induced immune thrombotic thrombocytopenia (VITT)Â after receiving a single dose of ChAdOX1-nCoV-19, AstraZeneca/Oxford vaccines.
PET and MRI detected myocardial inflammation and edema in a small proportion of patients diagnosed with acute myocarditis within 14 days of mRNA COVID-19 vaccination
PET and MRI visualization of myocardial tissue has shown localized myocardial inflammation and edema in a small proportion of patients with symptomatic myocarditis approximately two months after COVID-19 vaccination.Â
The mRNA COVID-19 vaccination increases the risk of retinal vascular occlusion
The overall risk of all forms of retinal vascular occlusion was 2.19 times higher in the vaccinated cohort than in the unvaccinated cohort within two years after COVID-19 vaccination.
