Inhibition of NHE1, an important pH-regulating plasma membrane protein, resulted in a reduction of pathological signatures and improved locomotor and cognitive recovery in a mouse model of repetitive mild TBI.
Neuroscience (in vitro & animal studies)
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Brain neurons form excitatory glutamatergic synapses with metastatic cells of non-neural cancers
This study has shown, for the first time, that neurons can form physiologically relevant excitatory glutamatergic synapses with metastatic cells of non-neural cancers.
Transfer of fecal materials from patients with Alzheimer’s disease to healthy rats resulted in cognitive deficit and impaired hippocampal neurogenesis
Transfer of fecal materials from Alzheimer’s disease patients to healthy young adult rats resulted in cognitive deficits and impaired hippocampal neurogenesis.
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Progress in tissue engineering: production of human two-layer cerebral cortical tissue and its ex vivo integration in mouse brainÂ
The authors fabricated the two-layer cerebral cortical tissue containing simplified cortical columns by a droplet-based 3D printing technique with human-induced pluripotent stem cells.
