The results show that a simplified two-layer cerebral cortical tissue can be produced using a droplet-based 3D-printing. Implantation of these constructs into ex vivo mouse brain explants demonstrated the structural integration of the implants and their correlated Ca2+ oscillations.
Brain regions most frequently affected by childhood abuse include the prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, corpus callosum, and cerebellum.
The majority of patients with locked-in syndrome remain severely disabled, but, even small improvements in function can significantly increase the potential for activity and participation.
Brain pathology in deceased athletes who played contact sports and were younger than 30 years of age at the time of death
41% of 152 young brain donors who were exposed to repeated head impacts and who donated their brain to the UNITE Brain Bank, had chronic traumatic encephalopathy
Rapid improvement of severe myelin oligodendrocyte glycoprotein antibody-associated disease in two children treated with the IL-6 receptor blocker-tocilizumab
IL-6 receptor blocker tocilizumab rapidly improved the condition in both patients with severe, acute manifestations of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).
Three metabolites as possible candidates for “toxic” gut–brain communication in patients with multiple sclerosis
Three metabolites from catabolism of two essential amino acids, tryptophan and phenylalanine, represent possible candidates for ‘toxic’ gut–brain communication in patients with multiple sclerosis.
The Pan American Health Organization as the regional office for the World Health Organization in the Americas issued a briefing note on July 10, 2023, regarding the unusual increase of cases of Guillain Barré Syndrome in different parts of Peru.
Higher risk of intracranial hemorrhage in healthy older people receiving daily low-dose aspirin (ASPREE randomized clinical trial)
The totals of intracranial hemorrhage resulting from a combination of hemorrhagic stroke and other causes of intracerebral hemorrhage, such as subdural, extradural, and subarachnoid bleeding, were significantly higher among individuals treated with aspirin than in individuals assigned to placebo.
Case report: a rare mutation in the complement factor I gene is associated with numerous episodes of recurrent aseptic meningitis
This case report demonstrated an association between a rare mutation in the complement factor I gene and numerous episodes of recurrent aseptic meningitis.
Autologous hematopoietic stem cell transplantation in 32 patients with aggressive relapsing-remitting multiple sclerosis
This study reports the results of autologous hematopoietic stem cell transplantation in 32 patients with relapsing-remitting multiple sclerosis.
The bone marrow is a previously unrecognized site that promotes intimate interactions between autoreactive T cells and hematopoietic cells. The autoreactive T lymphocytes augment myelopoiesis (but not lymphopoiesis) of hematopoietic stem cells and progenitor cells involving the CCL5-CCR5 axis.
In-depth review presented evidence for the eight hallmarks of neurodegenerative diseases (NDDs): pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA defects, inflammation, and neuronal cell death.
Spontaneous spinal cerebrospinal fluid-venous fistula as a cause of behavioral variant of fronto-temporal brain sagging syndrome
The behavioral variant of fronto-temporal brain sagging syndrome was investigated with digital subtraction myelography in the lateral decubitus position. The identification of a cerebrospinal fluid-venous fistula allows effective treatment, such as surgical ligation of the fistula.
Intracerebroventricular administration of soluble chemokine fractalkine after cuprizone-induced demyelination resulted in increased production of de novo oligodendrocytes and in vivo remyelination from activated parenchymal oligodendrocyte precursor cells.
The volumes of a callosal subregions terminating in the language-related posterior brain regions predict a stronger degree of language lateralization
The first tractography study that investigated the relation between the volumes and microstructural properties of callosal subregions and the degree of language lateralization. The volumes of callosal subregions terminating in the language-related posterior brain regions predicted a stronger degree of language lateralization.
This study has investigated changes in the organization of the neural network, neuronal metabolite concentrations and the structure of white or grey matter in the human brain during pregnancy and the postpartum period.