This study found abnormal accumulation of hyperphosphorylated tau proteins in the postmortem human brain samples of hippocampus and medial entorhinal cortex within 4-13 months after acute COVID-19.
Post-COVID/ Post-vaccination syndrome & Nervous system
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Reversible cerebral vasoconstriction syndrome after mRNA COVID vaccination (autopsy report)
Case report of patient who died of radiographically and pathologically confirmed reversible cerebral vasoconstriction syndrome (RCVS) one day after the third mRNA COVID (BNT162b2) vaccination.
Brain MR spectroscopy shows neuronal injury and glial dysfunction in patients with post-COVID neuropsychiatric symptoms
The observed changes in Glu/Gln balance, total N-acetyl-compound levels and MI provided evidence of neuronal injury or loss as ell as persistent neuroinflammation and glial dysfunction in the brains of post-COVID individuals, and are consistent with findings associated with brain damage in other neurodegenerative diseases, such as neuroHIV.
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Cognitive-linguistic difficulties in individuals with post-COVID syndrome
Participants diagnosed with Long COVID performed worse than healthy controls in delayed and immediate verbal recall, informativeness of spoken discourse, letter fluency, and category fluency for animals.
Brain functional connectome in individuals with primarily neurological symptoms of post-COVID syndrome
These findings demonstrate characteristics and changes of the complex network known as brain functional connectome in individuals with primarily neurological symptoms of post-COVID syndrome.
Multifocal necrotizing encephalitis, mild myocarditis, and endothelitis after COVID-19 vaccination (autopsy report)
This autopsy report described a case of multifocal necrotizing encephalitis, mild myocarditis, and pathological changes in small blood vessels (endothelitis) that developed after a third COVID-19 vaccination.
Correlation between increased [11C]PBR28 PET/MR brain signaling, as an indicator of neuroinflammation, and parameters of vascular health in post-acute COVID-19
The results provide indirect evidence that differences in PET signal across brain regions, as an indicator of neuroinflammation, could partially reflect variations in vascular health and perivascular immune infiltration in individuals with PASC.
The first onset or relapse of optic neuritis in COVID-19 vaccinated individuals positive for SARS-CoV-2
De novo onset or relapse of optic neuritis in vaccinated individuals infected with SARS-CoV-2.Â
The correlation of visuospatial deficits with the brain neuroimaging findings, and upregulation of certain biomarkers four months after acute COVID-19
Visuospatial deficit was associated with brain neuroimaging findings, and correlated with the upregulation of certain immune markers in approximately one-quarter of participants four months after acute COVID-19.
A new-onset small fiber neuropathy in individuals with post-acute COVID-19 syndrome
A case series of a new onset small fiber neuropathy with symptoms of dysautonomia and neuropathy, that developed after COVID-19.
Individuals with long COVID syndrome have reduced corneal innervation and increased density of corneal dendritic cells more than 20 months after acute COVID-19
These results show a decrease in corneal nerve density and branch density, as well as an increase in dendritic cell density in patients with long COVID in comparison to the control group.
Case series of hemorrhagic myelitis with poor clinical recovery after the SARS-CoV-2 infection
An uncommon disease, hemorrhagic myelitis was presented in three cases following SARS-CoV-2 infection, with minimal or no improvement during follow-up.
Acute disseminated encephalomyelitis (ADEM) can develop after acute SARS-CoV-2 infection or COVID-19 vaccination
A systematic review of the medical literature on cases of acute disseminated encephalomyelitis (ADEM) and acute hemorrhagic leukoencephalitis (AHLE) that occurred after severe acute SARS-CoV-2 infection or CoVID-19 vaccination.
Systemic reaction with predominant neurological and skin manifestations following the third dose of the mRNA-1273 COVID vaccine (case report)
A case of a systemic reaction, characterized by predominant neurological (electroencephalography and MRI findings) and skin manifestations (tinea inguinalis and tinea capitis) that occurred following the third dose of the mRNA-1273 vaccine,
Neuromyelitis optica spectrum disorder (NMOSD) can develop after acute SARS-CoV-2 infection or COVID-19 vaccination
The infection with SARS-CoV-2 and COVID-19 vaccination are associated with de novo onset or relapse of neuromyelitis optica spectrum disorder.
Transcranial magnetic stimulation demonstrated abnormal GABA-ergic and glutamatergic regulation of the motor cortex excitability in individuals with post-COVID syndrome and cognitive deficits
Patients diagnosed with long COVID syndrome and cognitive deterioration had significantly reduced long-interval intracortical inhibition that depends on slow inhibitory post-synaptic potentials mediated through GABA receptors and an abnormal pattern of intracortical facilitation, which is associated with glutamatergic excitatory signaling.
The presence of the SARS-CoV-2 spike protein in the skull-meninges-brain axis in the mouse model and human postmortem tissue samples
The findings of this study suggest an alternative route for the SARSCoV-2 S protein entry into the CNS, wherein it might reache first the skull marrow and meninges before entering the brain.
Individuals with post-COVID neuropsychiatric symptoms have abnormal brain activation during working memory tasks with lower activation of regions in the left hemisphere and  higher activation of regions in the right hemisphere
This is the first task-activated BOLD-fMRI study conducted in individuals diagnosed with post-COVID neuropsychiatric symptoms. The results discovered a different brain activity and reorganized working memory network in post-COVID participants compared to healthy controls who had no history of COVID-19 and tested negative for SARS-CoV-2.