Diseases & Drugs

A role of tau protein dysregulation in glaucomatous neurodegeneration

The thyroid-liver axis in the context of early Parkinson disease

The Japanese researchers used nuclear medicine techniques, trans-omic analysis of blood samples, and cultured cell experiments to examine how dysautonomia in Parkinson’s disease affects the intricate connection between the thyroid gland and the liver.

Cardiac dysfunction in stroke

The review discusses the main pathophysiological mechanisms of heart-brain interaction leading to the neurogenic cardiac injury.

Violence against women with disabilities

Persons with disabilities experience more violence in their lifetime than non-disabled persons, and are three times more likely to be sexually assaulted. Physical and sexual abuse against women with disabilities is more frequent, even about twice as common as for women without disabilities.

RNA-sequencing of amniotic fluid cells as a prenatal diagnostic tool

The findings demonstrate that RNA-sequencing of amniotic fluid cells could be implemented in a clinical setting as a complementary diagnostic tool to whole exome sequencing and whole genome sequencing, to provide functional evidence for variants affecting expression or splicing that cannot be explained by DNA sequencing.

Nanomaterials can cross the placental barrier and cause fetal damage

Due to their unique physicochemical properties, nanoparticles can directly cross the placenta and cause damage to the fetus, resulting in various fetal abnormalities. Nanotoxicity at the maternal–fetal interface involves various underlying molecular mechanisms such as oxidative stress, DNA damage, apoptosis, and autophagy.


The impact of childhood abuse on structural brain changes

An unusual outbreak of Guillain Barré Syndrome in Peru

The Pan American Health Organization as the regional office for the World Health Organization in the Americas issued a briefing note on July 10, 2023, regarding the unusual increase of cases of Guillain Barré Syndrome in different parts of Peru.

The eight hallmarks of neurodegenerative diseases

In-depth review presented evidence for the eight hallmarks of neurodegenerative diseases (NDDs): pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA defects, inflammation, and neuronal cell death.

Physiology, Pathophysiology, and Clinical Presentations of Gender Differences

Gender differences in AMPA glutamatergic transmission in the murine medial prefrontal cortex

An increase of synaptosomal expression of the GluA1 and GluA2 AMPA receptor subunits has been found in the medial prefrontal cortex of females compared with males. In addition, ex vivo slice electrophysiology performed on tissues prepared from the medial prefrontal cortex demonstrated a higher amplitude and frequency of spontaneous excitatory postsynaptic currents in female mice than in males.