These studies found an association between COVID-19 infection or vaccination and newly diagnosed or recurrent uveitis.
human endogenous retroviruses
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An increase in Guillain-Barré Syndrome cases in Maharashtra (India)
According to the Director General of the Indian Council of Medical Research, they are still investigating the cause behind the sudden spike in GBS cases in Maharashtra.
Higher serum ferritin levels distinguish long COVID patients who subsequently developed a clinical diagnosis of ME/CFS from those who did not meet the ME/CFS criteria
This study revealed that patients with long COVID who developed ME/CFS based on all of the three internationally standardized criteria had increased serum ferritin levels, identifyng serum ferritin as a possible biomarkers for detecting the transition to an ME/CFS condition, especially in female patients.
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In a 7-year follow-up, 61% of patients diagnosed with type 2 diabetes who had no cardiovascular disease were found to have subclinical left ventricular dysfunction
Type 2 diabetes is an independent risk factor for subclinical left ventricular dysfunction in asymptomatic patients without cardiovascular diseases.
A Korean nationwide study with 558,017 participants found that COVID-vaccinated individuals had a higher incidence of Alzheimer’s disease and mild cognitive impairment
The findings showed an increased incidence of Alzheimer’s disease and its prodromal stage, mild cognitive impairment, in COVID-vaccinated individuals, particularly those receiving mRNA vaccines, within three months post-vaccination.
Orthostatic intolerance associated with decreased levels of circulating growth hormone was found in long COVID patients under 20 years of age
This study showed a high rate (38%) of standing test positivity in patients with long COVID. The ST-positive long COVID patients under 20 years of age had decreased circulating growth hormone levels.
By blocking the MAPK and NF-κB signaling pathways, pomegranate peel extract reduces inflammation and alleviates symptoms in a rat model of irritable bowel syndrome
These findings underline the potential of PPE in the treatment of intestinal diseases.
The P3 peptide of the SARS-CoV2 spike protein shares sequence homology with Staphylococcus aureus superantigens and several endogenous mammalian proteins and induces T-cell proliferation
This study identified a small peptide P3 in the S2 subunit of the SARS-CoV2 S protein with sequence homology to bacterial superantigens and the capacity to induce unexpected proliferation of T-cells.
Genomic analyses of Staphylococcus aureus isolates show bacterial adaptation to COVID-19 selective pressure
Comparative genomic analysis of a collection of 339 S. aureus isolates from patients with bacteremia highlighted bacterial adaptation to COVID-19 selective pressure.
Relationship between the metabolic pathways associated with low serum vitamin D levels and the neurodevelopment measure (the ASQ communication score)
Low levels of vitamin D were associated with changes in the metabolic networks of tryptophan metabolism, linoleic acid metabolism, and unsaturated fatty acid biosynthesis.
The first report of a critically ill pediatric patient with avian influenza A(H5N1) infection, respiratory and renal failure (and consistently higher viral concentrations in the lower respiratory tract) in North America
The authors from Canada reported a severe avian influenza A(H5N1) illness in a 13-year-old adolescent with respiratory failure, left lower lobe pneumonia, acute kidney injury, thrombocytopenia, and leukopenia.
A low level of insulin-like growth factor 1 (IGF-1) in liver cirrhosis is an independent risk factor for decompensation, acute-on-chronic liver failure, and liver-related mortality
Lower levels of IGF-1 were an independent risk factor for further decompensation, acute-on-chronic liver failure and liver-related mortality, highlighting the clinical significance of low IGF-1 in liver cirrhosis.
Radial artery thrombosis occurred in 13% of individuals who underwent coronary angiography via the proximal transradial route
This study investigated the occurrence of radial artery thrombosis following the transradial route of coronary angiography and related risk factors for its occurrence.
An advanced MRI technique, quantitative susceptibility mapping at 7 T, revealed microstructural brainstem abnormalities in COVID-19 survivors over months after hospitalization
Non-invasive ultra-high-field 7 T QSM showed imaging evidence of pathophysiological changes and microstructural abnormalities in the brainstem over months after COVID-19 hospitalization.
Neurological symptoms and cognitive impairment were more prevalent in younger and middle-aged patients with neuro-long COVID, and they reported lower quality of life than older patients
Age-related differences in neuro-long COVID showed that younger and middle-aged patients were more severely affected than older patients.
SARS-CoV-2 infection triggers the cellular senescence pathway in susceptible dopaminergic neurons derived from human pluripotent stem cells (increased risk of viral-induced parkinsonism?)
This study demonstrated selective in vitro vulnerability of purified DA neurons derived from human pluripotent stem cells to SARS-CoV-2 infection and the associated inflammatory and cellular senescence response.Â
Treatment of postpartum constipation using Transcutaneous Tibial Nerve Stimulation (TTNS)
Bilateral TTNS, integrated with traditional physical therapy with diaphragmatic and abdominal exercises, improved constipation symptoms and quality of life in postpartum women.
18% of patients with post-COVID-19 vaccination syndrome were found to have autoantibodies against peripheral nerve structures
This study has shown that serum prevalence of autoreactive IgGs against peripheral nerve structures was significantly higher in PCVS patients than in healthy controls. IgG binding was directed against axons, paranodes, Schmidt-Lanterman incisures, and Schwann cell nuclei.
The attachment pattern, replication, and infection of the upper and lower human respiratory tract differ between the H5N1 virus of clade 2.3.4.4b, the H5N1 virus of clade 2.1.3.2 and a seasonal H3N2 virus
Currently circulating the HPAI H5N1 virus of clade 2.3.4.4b attached better to the human respiratory tract than the H5N1 virus of clade 2.1.3.2. More abundant attachment to the human respiratory tract of the H5N12022 virus was associated with its more effective replication.
Postmortem brain samples from COVID-19 convalescents who died within 4-13  months of acute infection showed an Alzheimer’s disease-like increase in hyperphosphorylated tau protein
This study found abnormal accumulation of hyperphosphorylated tau proteins in the postmortem human brain samples of hippocampus and medial entorhinal cortex within 4-13 months after acute COVID-19.
The striking molecular mimicry between SARS-CoV-2 and human EnaC-alpha may contribute to reduced reabsorption of alveolar fluid at the air-liquid interface
SARS-CoV-2 S protein may compete for the same processing protease with EnaC-alpha, a sodium permeable ion channel that controls fluid reabsorption at the air–liquid interface.
The risk of transmission of influenza A H5N1 virus through direct contact with raw milk from infected dairy cows (the mammary gland of cows abundantly displays receptors for circulating 2.3.4.4b H5 viruses)
Recent studies have investigated the ongoing risk of transmission of highly pathogenic avian influenza (HPAI) A(H5N1) virus to humans through direct contact with raw milk from infected dairy cows, the binding of 2.3.4.4b H5 influenza A viruses to available receptors in the mammary gland tissue samples from cows.
The sex-specific proteomic profiles of patients with heart failure and reduced ejection fraction
Circulating proteins associated with extracellular matrix organization were overrepresented in women, while those reflecting apoptotic processes were overrepresented in men. The predictive value of circulating proteins measured repeatedly did not differ between sexes, except for endothelin-1 and somatostatin.
Passive transfer of IgG from patients with long COVID induces mechanical and thermal sensitivity and impairs locomotor activity in mice
These findings demonstrate that transfer of IgG from long COVID patients to mice replicates disease symptoms, underscoring a causative and heterogeneous role of IgG in the pathogenesis of long COVID.
Testosterone, TMPRSS-2 and P450 aromatase are markers for the severity of COVID-19 (testosterone as a regulator of TMPRSS2 expression)
Hospitalized patients with COVID-19 were found to have higher TMPRSS-2 and P450 aromatase levels and lower testosterone levels, suggesting that TMPRSS2, testosterone, and P450 aromatase can be used as markers of poor prognosis or increased disease severity in COVID-19.
The rapid waning of serum antibodies after mRNA vaccination is due to the inability of mRNA vaccines to induce long-lived plasma cells in the bone marrow
This study showed the exclusion of SARS-CoV-2 specificity from the bone marrow long-lived plasma cell (LLPC) compartment and the inability of mRNA vaccines to induce necessary precursor programs to fully mature into the bone marrow LLPC.
SARS-CoV-2 antigens can persist in plasma for up to 14 months after acute infection
Analysis of temporal antigen profiles, performed by collecting blood samples at multiple time points, revealed that the prevalence of SARS-CoV-2 plasma antigens was 10.6% 3-6 months after the onset of COVID-19, 8.7% after 6-10 months and 5.4% after 10-14 months.
The XEC variant of SARS-CoV-2 exhibits higher pseudovirus infectivity and immune evasion
SARS-CoV-2 XEC variant exhibited a higher pseudovirus infectivity and immune evasion compared to KP.3, indicating that XEC will be a predominant SARS-CoV-2 variant in the near future.
14% of Texas dairy farmworkers tested had elevated levels of neutralizing antibodies against a recombinant Influenza A(H5N1) virus of clade 2.3.4.4b
Experts are warning that human cases of the H5N1 avian flu could be going undetected due to poor surveillance and a lack of diagnostic testing in at-risk groups.
The persistence of residual SARS-CoV-2 RNA or proteins in different tissue samples four months after infection
This study showed the persistence of SARS-CoV-2 nucleic acid in solid tissue samples from various organs, including lung, liver, kidney, stomach, intestine, brain, breast, thyroid, blood vessels, and skin, in patients who had recovered from mild COVID-19 at one month, two months, and four months post-infection.
Diffusion tensor imaging revealed brain abnormalities in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Diffusion tensor imaging parameters were used to investigate microstructural abnormalities of brain tissue in individuals diagnosed with ME/CFS
Hypertrophic tonsils as the SARS-CoV-2 reservoir in children: 23% of tonsil and adenoid tissue samples of children who had undergone adenotonsillectomy, were positive for the SARS-CoV-2 nucleoprotein
A discovery of the structural SARS-CoV-2 protein in situ in adenoids and palatine tonsils, in both epithelial and lymphomononuclear cells of different lymphoid compartments, suggests that the tonsils may be sites of prolonged infection, even without recent COVID-19 symptoms.
The carbohydrate ProLectin M increased viral clearance in patients with mild to severe COVID-19 by antagonizing the binding of galectin-3 to the S1 subunit of the SARS-CoV-2
The carbohydrate PL-M can reduce the viral load in Vero cells. In clinical studies with COVID-19 patients, PL-M treatment resulted in a rapid reduction of viral load and increased viral clearance, with no adverse effects.