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A discovery of the structural SARS-CoV-2 protein in situ in adenoids and palatine tonsils, in both epithelial and lymphomononuclear cells of different lymphoid compartments, suggests that the tonsils may be sites of prolonged infection, even without recent COVID-19 symptoms.
The carbohydrate PL-M can reduce the viral load in Vero cells. In clinical studies with COVID-19 patients, PL-M treatment resulted in a rapid reduction of viral load and increased viral clearance, with no adverse effects.
This study revealed increased IgE levels specific for the receptor binding domain (RBD) of the SARS-CoV-2 in individuals who had been immunized with the ChAdOx1, CoronaVac and mRNA BNT162b2 vaccines. Additionally, IgG4 levels detected after booster mRNA BNT162b2 vaccination, showed a moderate correlation with IgE levels.
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This study described a case series of 28 patients who experienced de novo onset or flares of psoriasis following infection with the SARS-CoV-2 or vaccination. All of these patients were successfully managed with anti-IL-17 or anti-IL-23 medications.
This study is the first to show that the SARS-CoV-2 spike protein acts as an allosteric agonist of β1- and β2 adrenergic receptors, which activates β-adrenergic receptors in cardiomyocytes and contributes to cardiac sympathetic hyperactivity.
The S1 protein activates human CFs by priming NLRP3 inflammasomes through NF-κB signaling in an ACE2-dependent way.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect the human placenta. In this study, the authors from Italy performed immunohistochemical analyses to determine whether SARS-CoV-2 alters markers involved in vascular damage and the autophagic...
These results demonstrated that nAChR subtypes interact with the neurotoxin-like region of the SARS-CoV-2, confirming that the α7 nAChR is a target for the SARS-CoV-2.
This study found, for the first time in children, that levels of IgG4 antibodies specific for S1 and RBD significantly increased one year after the second vaccination compared to baseline.
SARS-CoV-2 enters human erythrocytes, but in a low percentage of cells (10.9%) compared to SARS-CoV-2 permissive cell lines. The presence of SARS-CoV-2 in blood culture did not affect the survival or growth rate of the malaria parasite.
This case report describes a fully vaccinated woman positive for a non-Omicron variant of SARS-CoV-2 who experienced a spontaneous internal carotid dissection. A dissection was treated successfully with a flow-diverter stent.
Immune modulation associated with exposure to Plasmodium falciparum may contribute to a reduced severity of SARS-CoV-2 infection among people living in malaria-endemic regions
This study showed a dose-dependent antiviral effect of a uricosuric agent probenecid in patients with symptomatic, mild-to-moderate COVID-19.
Numerous studies demonstrated the positive effects of quercetin in in COVID-19 or post-COVID-19 syndrome, including direct inhibition of viral entry into the host cells, inhibition of viral replication, anti-inflammatory, antioxidant, immunomodulatory and neuroprotective effects.
Inhibition of NHE1, an important pH-regulating plasma membrane protein resulted in a reduction of pathological signatures and improved locomotor and cognitive recovery in a mouse model of repetitive mild TBI.
The Department of Health and National Notifiable Diseases Surveillance System of the Australian Government reported a rise in the prevalence of cryptosporidiosis in Australia.
The BNT162b2 mRNA COVID-19 vaccine directly affects the activity of ovarian granulosa cells, which is a unique, independent mechanism for vaccine-related menstrual abnormalities.
Histamine receptor H1 acts as an independent receptor for SARS-CoV-2. Additionally, H1 directly interacts with ACE2, synergistically enhancing ACE2-dependent viral entry.
This study analyzes recent research on natural products derived from plants, honey, and marine sponges with properties against the SARS-CoV-2, as well as several potential mechanisms of their action,
Case report of patient who died of radiographically and pathologically confirmed reversible cerebral vasoconstriction syndrome (RCVS) one day after the third mRNA COVID (BNT162b2) vaccination.
This study, conducted in two large US prospective cohorts, found that consumption of olive oil reduces dementia mortality risk.
The Japanese National Institute of Infectious Diseases reports a rise in the number of patients with toxic shock syndrome in Japan.
This retrospective study of 4,520 pediatric patients infected with the Omicron variant of SARS-CoV-2 demonstrated that acute necrotizing encephalopathy and pneumonia with comorbidities were the main causes of death.
A rare case of COVID-19-associated unilateral encephalitis, characterized by severe involvement of the left cerebral hemisphere.
The observed changes in Glu/Gln balance, total N-acetyl-compound levels and MI provided evidence of neuronal injury or loss as ell as persistent neuroinflammation and glial dysfunction in the brains of post-COVID individuals, and are consistent with findings associated with brain damage in other neurodegenerative diseases, such as neuroHIV.
On December 8th, 2023, the World Health Organization announced that Zambia had reported its largest anthrax outbreak for a decade.
Seven antigenic sites of SARS-CoV-2 spike RBD showed molecular similarities with 54 antigenic determinants found in fifteen pathogen microorganisms, including bacteria, parasites and viruses.
These case reports presented individuals who were diagnosed with COVID-19 and who developed tuberculous pericarditis with tamponade.
The intranasal infection of K18-hACE2 mice with SARS-CoV-2 led to viral positivity in various parts of the eye, including the retina and the anterior segment tissue, and elevated viral titers in the lungs and brain.
Two randomized, placebo-controlled trials show that metformin reduces the viral load of SARS-CoV-2 and the incidence of long COVID syndrome.
Participants diagnosed with Long COVID performed worse than healthy controls in delayed and immediate verbal recall, informativeness of spoken discourse, letter fluency, and category fluency for animals.
After the second BNT162b2 mRNA vaccination, brachial artery flow-mediated dilation assessment showed endothelial dysfunction in relatively healthy participants, which was restored within six months.
This study showed an increased immune resistance of KP.2 variant and its ability to evade neutralizing antibodies to a greater extent than previous variants, including JN.1.