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The most remarkable finding in the cardiac remodeling triggered by the SARS-CoV-2 infection was a marked neovascularization in the form of intussusceptive angiogenesis, which was associated with a significant infiltration of CD11b+/TIE2+ macrophages, which are drivers of intussusceptive angiogenesis.
Azithromycin treatment was distinct in terms of enhancement of the epithelial barrier, retention of phospholipids, vesicle build-up, and its effect on gene sets related to keratinocyte differentiation and establishment of skin barrier.
The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.
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This work highlights different effects of SARS-CoV-2 S protein on both early and late stages of retinal development, and provides insights into the cellular and molecular mechanisms of these effects.
This cross-sectional study showed that chronic exposure to arthroplasty implants was associated with increased blood levels of cobalt, chromium, titanium, niobium, and zirconium. Arthroprosthetic cobalt, chromium, titanium, niobium, and zirconium seemed to cross blood-brain barrier and accumulate in CSF.
A follow-up study of immune parameters in unvaccinated COVID-19 convalescents 10 weeks and 10 months after a first and mostly mild infection with the Wuhan-strain Hu-1 showed a long-term reduction of innate and adaptive immune cells, associated with a shift from Th1 to Th2 cytokine pattern.
The gene expression in men with post-COVID syndrome differed from that of men who had recovered after COVID-19, with 399 differentially expressed genes (DEGs) compared to men who had recovered after COVID-19 and to control men. These DEGs showed high enrichment in genes related to erythrocyte development and differentiation and heme metabolism.
After discontinuation of anticoagulation therapy, recurrent VTE occurred in 3.5% of patients, with a rate of 3.1 per 100 patient-years, and no fatal pulmonary embolism.
Among adolescents and young adults, alcohol-associated pancreatic complications were more frequent than liver-related complications (29% versus 19% respectively), and the most frequent pancreatic complications were acute pancreatitis (92%).
PREFUL MRI parameters revealed subtle pulmonary changes in children and adolescents with post-COVID syndrome, such as reduced regional ventilation and perfusion.
This nationwide cohort study showed that the current use of antidepressants, in particular SSRIs (i.e., citalopram, sertraline, and escitalopram) and mirtazapine was associated with faster cognitive decline in patients with dementia.
This study demonstrated that, both before and after six months of B-cell depletion therapy, healthy people and MS patients had different host immunologic responses, particularly IgA-binding patterns to the gut microbiome.
This study demonstrated immunological and other characteristics in individuals experiencing persistent symptoms following COVID-19 vaccination.
Based on data available for the week ending February 8, 2025, this season is classified as a high severity season for all age groups (children, adults, older adults) for the first time since 2017-2018.
In these two systematic reviews, the authors examined the existing literature on chorea associated with COVID-19 infection or vaccination.
The authors concluded that the findings of sudden cardiac deaths attributable to COVID vaccine-related myocarditis warrant the careful monitoring or warning of sudden cardiac death as a potentially fatal complication of COVID-19 vaccination, especially in individuals younger than 45 years of age who received the mRNA vaccines.
These studies found an association between COVID-19 infection or vaccination and newly diagnosed or recurrent uveitis.
According to the Director General of the Indian Council of Medical Research, they are still investigating the cause behind the sudden spike in GBS cases in Maharashtra.
This study revealed that patients with long COVID who developed ME/CFS based on all of the three internationally standardized criteria had increased serum ferritin levels, identifyng serum ferritin as a possible biomarkers for detecting the transition to an ME/CFS condition, especially in female patients.
Type 2 diabetes is an independent risk factor for subclinical left ventricular dysfunction in asymptomatic patients without cardiovascular diseases.
The findings showed an increased incidence of Alzheimer’s disease and its prodromal stage, mild cognitive impairment, in COVID-vaccinated individuals, particularly those receiving mRNA vaccines, within three months post-vaccination.
This study showed a high rate (38%) of standing test positivity in patients with long COVID. The ST-positive long COVID patients under 20 years of age had decreased circulating growth hormone levels.
These findings underline the potential of PPE in the treatment of intestinal diseases.
This study identified a small peptide P3 in the S2 subunit of the SARS-CoV2 S protein with sequence homology to bacterial superantigens and the capacity to induce unexpected proliferation of T-cells.
Comparative genomic analysis of a collection of 339 S. aureus isolates from patients with bacteremia highlighted bacterial adaptation to COVID-19 selective pressure.
Low levels of vitamin D were associated with changes in the metabolic networks of tryptophan metabolism, linoleic acid metabolism, and unsaturated fatty acid biosynthesis.
The authors from Canada reported a severe avian influenza A(H5N1) illness in a 13-year-old adolescent with respiratory failure, left lower lobe pneumonia, acute kidney injury, thrombocytopenia, and leukopenia.
Lower levels of IGF-1 were an independent risk factor for further decompensation, acute-on-chronic liver failure and liver-related mortality, highlighting the clinical significance of low IGF-1 in liver cirrhosis.
This study investigated the occurrence of radial artery thrombosis following the transradial route of coronary angiography and related risk factors for its occurrence.
Non-invasive ultra-high-field 7 T QSM showed imaging evidence of pathophysiological changes and microstructural abnormalities in the brainstem over months after COVID-19 hospitalization.
Age-related differences in neuro-long COVID showed that younger and middle-aged patients were more severely affected than older patients.
This study demonstrated selective in vitro vulnerability of purified DA neurons derived from human pluripotent stem cells to SARS-CoV-2 infection and the associated inflammatory and cellular senescence response.Â
Bilateral TTNS, integrated with traditional physical therapy with diaphragmatic and abdominal exercises, improved constipation symptoms and quality of life in postpartum women.