Acute COVID-19 & Cardiovascular system (SARS-CoV-2 & Cardiac Tissue)

Marked neovascularization in the form of intussusceptive angiogenesis, associated with a significant infiltration of CD11b+/TIE2+ macrophages, may be the main driver for a specific cardiac injury induced by SARS-CoV-2

May 9, 2025

The most remarkable finding in the cardiac remodeling triggered by the SARS-CoV-2 infection was a marked neovascularization in the form of intussusceptive angiogenesis, which was associated with a significant infiltration of CD11b+/TIE2+ macrophages, which are drivers of intussusceptive angiogenesis.

The SARS-CoV-2 spike protein acts as an allosteric agonist of β-adrenergic receptors and contributes to sympathetic hyperactivity

Sep 7, 2024

This study is the first to show that the SARS-CoV-2 spike protein activates β-adrenergic receptors in cardiomyocytes, contributes to cardiac sympathetic hyperactivity and increases activation of downstream β-adrenergic receptor signaling induced by epinephrine.

SARS-CoV-2 S1 protein activates human cardiac fibroblasts by priming NLRP3 inflammasomes through NF-κB signaling in an ACE2-dependent way and promotes cardiac fibrosis

Sep 2, 2024

The S1 protein activates human CFs by priming NLRP3 inflammasomes through NF-κB signaling in an ACE2-dependent way.

Other Entries

SARS-CoV-2 infection and additional hypoxic stress deteriorates cardiac function and disrupts vascular network formation in human cardiac tissue model

Dec 31, 2023

Human iPS cell-based cardiac tissue model shows that cardiac tissue exposed to persistent SARS-CoV-2 infection is at high risk for cardiac dysfunction.

Patients with acute COVID-19 and convalescents who recovered after severe COVID-19 were found to have elevated levels of anti-desmoglein 2 autoantibodies

Apr 27, 2023

The results showed the possible association between anti-Dsg2 autoantibodies and post-COVID-19 cardiac sequelae.