The S1 protein activates human CFs by priming NLRP3 inflammasomes through NF-κB signaling in an ACE2-dependent way.
Acute COVID-19 & Cardiovascular System
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SARS-CoV-2 infection and additional hypoxic stress deteriorated cardiac function and disrupted vascular network formation in human cardiac tissue modelÂ
Human iPS cell-based cardiac tissue model shows that cardiac tissue exposed to persistent SARS-CoV-2 infection is at high risk for cardiac dysfunction.
Severe thickening and fibrosis of the vessel walls, and lumen occlusion were found in the placental arteries of women infected with SARS-CoV-2
The results show severe vascular remodeling of placental arteries, including severe thickening of the vessel walls and the occlusion of the vessel lumen, in women with COVID-19 during pregnancy.
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SARS-CoV-2 can infect atherosclerotic plaques in human coronary arteries
SARS-CoV-2 was detected and replicated in the coronary arteries sampled at autopsy of severe COVID-19 cases. The virus targeted plaque macrophages and demonstrated a stronger tropism for arterial wall lesions than for perivascular fat.
Patients with acute COVID-19 and convalescents who recovered after severe COVID-19 were found to have elevated levels of anti-desmoglein 2 autoantibodies
The results showed the possible association between anti-Dsg2 autoantibodies and post-COVID-19 cardiac sequelae.Â
