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This study revealed increased IgE levels specific for the receptor binding domain (RBD) of the SARS-CoV-2 in individuals who had been immunized with the ChAdOx1, CoronaVac and mRNA BNT162b2 vaccines. Additionally, IgG4 levels detected after booster mRNA BNT162b2 vaccination, showed a moderate correlation with IgE levels.
This study found, for the first time in children, that levels of IgG4 antibodies specific for S1 and RBD significantly increased one year after the second vaccination compared to baseline.
Two cases of immunoglobulin (Ig)G4-related diseases that developed after COVID vaccination.
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The authors present a patient who developed the ocular manifestation of immunoglobulin (Ig)G4-related disease, referred to as IgG4-related ophthalmic disease (IgG4-ROD), after COVID vaccination.
Irrgang et al were the first to report an increase in the proportion of IgG4 antibodies specific for SARS-CoV-2 spike protein, starting after the second and increasing further after the third mRNA COVID vaccination.
