These findings suggest that the persistence of vaccine-derived S1 protein in CD16+ monocytes, and post-acute sequelae of COVID-19-like cytokine profile, may contribute to persistent post-COVID-19 vaccination syndrome.
Category
Post COVID-19-vaccination syndrome & Immunity
Latest content
One year after mRNA COVID-19 immunization, the young people show elevated cytokine levels, suggesting ongoing stimulation of the immune system
The results showed that vaccination led to increased cytokine levels even one year after vaccination. Furthermore, the results indicated differences in cytokine levels based on gender and age.
Individuals with post-COVID vaccination syndrome were found to have a specific immunological profile, serological evidence of recent Epstein-Barr virus reactivation, and circulating SARS-CoV-2 S1 protein up to 700 days after vaccination
This study demonstrated immunological and other characteristics in individuals experiencing persistent symptoms following COVID-19 vaccination.
Other Entries
Autoantibodies against peripheral nerve structures have been found in 18% of patients with post-COVID-19 vaccination syndrome
This study has shown that serum prevalence of autoreactive IgGs against peripheral nerve structures was significantly higher in PCVS patients than in healthy controls. IgG binding was directed against axons, paranodes, Schmidt-Lanterman incisures, and Schwann cell nuclei.
The rapid waning of serum antibodies after mRNA vaccination is due to the inability of mRNA vaccines to induce long-lived plasma cells in the bone marrow
This study showed the exclusion of SARS-CoV-2 specificity from the bone marrow long-lived plasma cell (LLPC) compartment and the inability of mRNA vaccines to induce necessary precursor programs to fully mature into the bone marrow LLPC.
Differences in the concentrations of autoantibodies against receptors involved in autonomic regulation between individuals with post-COVID-19 vaccination syndrome and vaccinated healthy subjects could be related to dysautonomia
The concentrations of autoantibodies against receptors involved in autonomic regulation and serum levels of IL-6/IL-8 can distinguish individuals with post-COVID-19 vaccination syndrome from healthy vaccinated individuals.
A significant proportion (29%) of healthcare workers developed de novo production of antinuclear antibodies after three mRNA COVID-19 vaccinations
A significant proportion (29%) of healthcare workers developed de novo production of antinuclear antibodies after three mRNA COVID-19 vaccines. The most prevalent was a homogeneous pattern of ANA.
Vaccinated COVID convalescents were found to have increased T-cell activation in many anatomical regions and SARS-CoV-2-specific RNA in rectosigmoid cells up to 2.5 years after initial infection
A whole-body positron emission tomography with a novel radiopharmaceutical [18F]F-AraG showed increased T cell activation in numerous anatomical regions in vaccinated COVID convalescents up to 2.5 years after initial SARS-CoV-2 infection.
Changes in cytokine responses to heterologous pathogens and SARS-CoV-2 antigens were observed in children aged 5 to 11 years up to six months after their second BNT162b2 mRNA vaccination
Since a decrease in immune response to other pathogens makes children more susceptible to other infections, the authors concluded that these findings highlight the need for further consideration of vaccination policy.
