Topic
A follow-up study of immune parameters in unvaccinated COVID-19 convalescents 10 weeks and 10 months after a first and mostly mild infection with the Wuhan-strain Hu-1 showed a long-term reduction of innate and adaptive immune cells, associated with a shift from Th1 to Th2 cytokine pattern.
This study identified a small peptide P3 in the S2 subunit of the SARS-CoV2 S protein with sequence homology to bacterial superantigens and the capacity to induce unexpected proliferation of T-cells.
These findings demonstrate that transfer of IgG from long COVID patients to mice replicates disease symptoms, underscoring a causative and heterogeneous role of IgG in the pathogenesis of long COVID.
Immune modulation associated with exposure to Plasmodium falciparum may contribute to a reduced severity of SARS-CoV-2 infection among people living in malaria-endemic regions.
This study demonstrates diversity of intracellular microbes in immune cells of healthy individuals, SARS-CoV-2 positive patients, and COVID-19 recovered individuals.
The findings suggest that higher levels of autoantibodies directed against specific chemokines are associated with favorable disease outcomes in COVID-19 convalescents.
Individuals with neuro-PASC had a distinct pattern of T cell activation and specific immune responses against the SARS-CoV-2 nucleocapsid protein.
Unique monocyte signatures define subgroups of long COVID patients and confirm prolonged changes in innate immunity during COVID-19 convalescence. Given the heterogeneity of clinical presentations, it seems likely that distinct pathophysiological pathways cause different long COVID phenotypes
According to the authors, high levels of SARS-CoV-2 S protein genetic diversity in individuals with advanced poorly controlled HIV infection markedly increase the risk for the emergence of new VOCs in these individuals.
