Please consider supporting DiscoverMedNews


Cerebrovascular lesions and vascular abnormalities in children with SARS-CoV-2 Omicron infection (MRI study)

Prior studies have found neurological involvement and abnormal neuroimaging findings in pediatric patients infected with earlier variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These neuroimaging findings included acute disseminated encephalomyelitis, lesions of the corpus callosum, cauda equina nerve root enhancement, bilateral thalamic signal changes, micro-hemorrhages, and leukoencephalopathy. The researchers from Taiwan conducted this retrospective study to evaluate the brain magnetic resonance imaging (MRI) and MR angiography (MRA) findings in hospitalized children with SARS-CoV-2 Omicron infection and severe neurological manifestations, with a focus on cerebrovascular lesions and vascular abnormalities. The authors noted that the incidence of pediatric hospitalizations has increased significantly with the spread of the Omicron variant.


About the study

This retrospective study included children diagnosed with COVID-19 who underwent brain MRI and MRA for neurological symptoms. All patients tested positive for SARS-CoV-2 by reverse transcriptase polymerase chain reaction (rt-PCR). Demographics and clinical and laboratory data were also collected.

Two pediatric neurologists and one pediatric radiologist reviewed the MRI images. They evaluated the presence of signal abnormalities, the locations of lesions, and the cerebral vascular changes. The researchers noted that MRI was done only in children with severe neurological manifestations, and not in children with milder symptoms.



A total of 31 pediatric patients, 11 females, and 20 males, underwent MRI due to neurological symptoms resulting from the COVID-19 infection. All patients presented with fever and/or upper respiratory symptoms. None of them had acute severe pulmonary disease, respiratory distress syndrome, or other severe non-neurological manifestations. One patient had hepatitis, possibly as an adverse effect of remdesivir treatment. Although approximately 50% of the children infected with earlier SARS-CoV-2 strains who developed neurological complications met the criteria for a multisystemic inflammatory syndrome in children (MIS-C), in this study no case met the criteria for MIS-C.

The median age was six years (ranging from three months to 13 years).

The median time from diagnosis of COVID-19 to MRI examination was 26 days (0–97 days). The median time from the onset of neurological manifestations to MRI examinations was 20 days (0–97 days) for all patients and 11 days (0–97 days) for patients with abnormal MRI findings

The majority of pediatric patients had seizures as a neurological symptom (35.5%). This result is consistent with the results of a recent Japanese nationwide epidemiological study that demonstrated that seizures, impaired consciousness, and abnormal speech and behavior were the first symptoms of acute encephalopathy associated with Omicron infection in more than 90% of unvaccinated pediatric cases.

Other neurological symptoms included visual hallucinations (19.4%), altered mental status (16.1%), headaches (9.7%), myoclonus (9.7%), hemiplegia (3.2%), tics (3.2%), gait disturbance (3.2%), and parasomnia (3.2%). 


MRI findings

Out of 31 patients, MRI abnormalities were found in 48.4% (15 patients). 73.3% of patients with abnormal findings on MRI had encephalitis/encephalopathy. Other MRI abnormalities included ischemic stroke in 3.2%, hemorrhages in 13.3%, and Alice in Wonderland syndrome in 6.7% of pediatric cases. 

The analysis of the lesion location

Two patients had diffuse cortical T2 and/or DWI hyperintensity. Focal lesions were detected in the cerebral cortex and thalamus in one patient, the medulla in one patient, the pons in two patients, the cerebellum in one patient, the splenium of the corpus callosum in one patient, and globus pallidus, subthalamic regions, and cerebral peduncles in one patient.

Neurological symptoms, such as decreased level of consciousness, central apnea, and loss of oculocephalic reflex accompanied the MR findings in the brainstem (the pons and medulla).

Three children with SARS-CoV-2 Omicron infection developed ischemic strokes, an eight-year-old boy with seizures and impaired consciousness, a twelve-year-old boy with abrupt onset of hemiplegia, and a four-year-old girl with epilepsia partialis continua.

Four patients had poor neurological outcomes, all of them had abnormal MRI findings, and two children had vascular abnormalities.

Importantly, a high proportion of patients (80%) had abnormal MRA findings in medium or large intracerebral vessels, whereas infarction in small vessels was found in 8.8%. Two patients had abnormal MRA findings in the anterior cerebral arteries (ACA), seven patients in the middle cerebral arteries (MCA), two patients in the posterior cerebral arteries (PCA), and three patients in the internal carotid arteries (ICA).


Original figure from the article of Yen-Ju Chu et al. 2024. (A–C) 7-year-old girl with encephalitis and myoclonic status epilepticus. Restricted diffusion at the bilateral thalami and parietal, occipital, and temporal cortex. MRA showing narrowing of bilateral MCA and proximal right ACA.  (D–F) A 10-year-old female with surgically corrected tetralogy of Fallot and new-onset seizure. Multiple petechial hemorrhages on susceptibility-weighted imaging.  MRA showing narrowing and beading of left MCA. (G–I) 12-year-old boy with hemiplegia. Restricted diffusion at left thalamus and rostrum of corpus callosum. Interrupted flow signal at left distal MCA.




This study has shown cerebrovascular lesions and vascular abnormalities in a high proportion (48.4%) of children with SARS-CoV-2 Omicron infection and severe neurological manifestations.

Importantly, a high proportion of patients (80%) had abnormal MRA findings in medium or large intracerebral vessels, whereas infarction in small vessels was found in 8.8%. According to the authors, some of the MRI findings in these patients suggest brain damage related to vasculitis. However, the underlying mechanisms and pathophysiology of observed large cerebral vessel occlusion in children with SARS-CoV-2 Omicron infection remain unknown.


This article was published in the Journal of the Formosan Medical Association. 


Journal Reference

Yen-Ju Chu, Lee-Chin Wong, Wen-Chin Weng, et al. High incidence of cerebrovascular lesions on magnetic resonance imaging in pediatric COVID-19 during omicron outbreak – A retrospective case series. Journal of the Formosan Medical Association, 2024. (Open Access) 


Learn How to Go Paperless on PDFelement Wondershare EdrawMind