This retrospective study of 4,520 pediatric patients infected with the Omicron variant of SARS-CoV-2 demonstrated that acute necrotizing encephalopathy and pneumonia with comorbidities were the main causes of death.
Acute COVID-19 in Children/Adolescents
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Cerebrovascular lesions and brain vascular abnormalities in children infected with the Omicron variant of SARS-CoV-2 (MRI study)
This study has shown cerebrovascular lesions and vascular abnormalities in a high proportion (48.4%) of children with severe neurological manifestations of infection with the Omicron variant of SARS-CoV-2.
Acute encephalopathy in unvaccinated children infected with the Omicron variant of SARS-CoV-2 (Japanese nationwide epidemiological study)
A significantly higher number of patients with SARS-CoV-2-associated acute encephalopathy experienced severe disability or even death than patients with acute encephalopathy not associated with SARS-CoV-2.
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Pediatric patients with the Omicron variant of SARS-CoV-2 have a higher rate of simple or complex febrile seizures compared to children infected with non-Omicron variants
The Omicron variant of SARS-CoV-2 was associated with a higher rate of febrile seizures and unconsciousness in infected children compared to non-Omicron variants.
Differently expressed human endogenous retroviruses (HERVs) and immune mediators in children diagnosed with COVID-19, Kawasaki disease, or multisystem inflammatory syndrome in children (MIS-C)
HERV-related genes, HERVs, and immune mediators are differently upregulated in children diagnosed with acute COVID-19, acute or subacute KD, and acute or subacute MIS-C, supporting the role of HERVs in inflammatory diseases and their interaction with the immune system.Â
