This work highlights different effects of SARS-CoV-2 S protein on both early and late stages of retinal development, and provides insights into the cellular and molecular mechanisms of these effects.
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Acute COVID-19 & Other body systems
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Testosterone, TMPRSS-2 and P450 aromatase are markers for the severity of COVID-19 (testosterone as a regulator of TMPRSS2 expression)
Hospitalized patients with COVID-19 were found to have higher TMPRSS-2 and P450 aromatase levels and lower testosterone levels, suggesting that TMPRSS2, testosterone, and P450 aromatase can be used as markers of poor prognosis or increased disease severity in COVID-19.
Highly expressed markers of vascular impairment and autophagy are co-localized with SARS-CoV-2 spike protein in placenta samples of unvaccinated women positive for SARS-CoV-2
Increased expression of VEGF and the endothelial cell marker CD34 indicates alterations, disarrangements, or remodeling of normal vasculature, associated with vascular endothelial injury and endothelitis.
Other Entries
SARS-CoV-2 enters human erythrocytes but does not affect the development of Plasmodium falciparum
SARS-CoV-2 enters human erythrocytes, but in a low percentage of cells (10.9%) compared to SARS-CoV-2 permissive cell lines. The presence of SARS-CoV-2 in blood culture did not affect the survival or growth rate of the malaria parasite.
Tuberculous pericarditis with pericardial tamponade in SARS-CoV-2-positive patients (Two case reports)
These case reports presented individuals who were diagnosed with COVID-19 and who developed tuberculous pericarditis with tamponade.
Intranasal infection of mice with SARS-CoV-2 led to retinal inflammation and elevated viral titers in the lungs and brain
The prolonged presence of SARS-CoV-2 S protein in ocular tissues (thirty days after the intravitreal injection) resulted in microaneurysms, retinal atrophy, and retinal vein occlusion.
SARS-CoV-2 preferentially infects intestinal cells via their apical side and causes damage to the intestinal epithelial barrier
Inoculation of SARS-CoV-2 at the apical pole resulted in the severe damage to the integrity of the intestinal epithelial barrier, suggesting that the virus present in the intestinal lumen could damage the intestinal epithelial barrier, enter the blood vessels and spread to various organs.
HERV-W envelope proteins detected in plasma, blood cells and postmortem tissues of severe COVID-19 patients could serve as biomarkers of COVID-19 severity
SARS-CoV-2 can induce the expression of the HERV-W envelope proteins, suggesting their involvement in COVID-19-associated pathology.
SARS-CoV-2 can infect hepatocytes and stimulate hepatic glucose production through gluconeogenesis
SARS-CoV-2 can infect, replicate, and produce infectious viral particles in primary human hepatocytes and stimulate their production of glucose through gluconeogenesis.
