This study identified a small peptide P3 in the S2 subunit of the SARS-CoV2 S protein with sequence homology to bacterial superantigens and the capacity to induce unexpected proliferation of T-cells.
Category
Homology between Viral and Human/Other Antigens
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The striking molecular mimicry between SARS-CoV-2 and human EnaC-alpha may contribute to reduced reabsorption of alveolar fluid at the air-liquid interface
SARS-CoV-2 S protein may compete for the same processing protease with EnaC-alpha, a sodium permeable ion channel that controls fluid reabsorption at the air–liquid interface.
“Neurotoxin-like region” of the SARS-CoV-2 spike protein modulates nicotinic acetylcholine receptors (with a high preference for the α7 subtype linked with aggression, anxiety, and depression)
Neurotoxin-like region of the SARS-CoV-2 interact with the nicotinic acetylcholine receptors. The α7 nAChR is a target for the SARS-CoV-2.
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Molecular similarities between antigenic sites of the SARS-CoV-2 RBD and 54 antigenic determinants of fifteen pathogens (bacteria, parasites, and viruses)
Seven antigenic sites of SARS-CoV-2 spike RBD showed molecular similarities with 54 antigenic determinants found in fifteen pathogen microorganisms, including bacteria, parasites and viruses.
