This study demonstrated that, both before and after six months of B-cell depletion therapy, healthy people and MS patients had different host immunologic responses, particularly IgA-binding patterns to the gut microbiome.
Category
Neuroscience (Multiple Sclerosis)
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Intrathecally synthesized IgG1/CXCL10 axis is a potential predictor of multiple sclerosis activity
A specific signaling axis, immunoglobulin (Ig)G1-CXC motif chemokine ligand 10 (CXCL10), is a potential predictor of MS disease activity and/or conversion from clinically isolated syndrome to relapsing-remitting MS.
HERV expression in pregnant women with multiple sclerosis is reduced compared to healthy pregnant women
The expression of HERVs in pregnant women with MS was reduced compared to healthy pregnant women.
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Autologous hematopoietic stem cell transplantation in 32 patients with aggressive relapsing-remitting multiple sclerosis
This study reports the results of autologous hematopoietic stem cell transplantation in 32 patients with relapsing-remitting multiple sclerosis.
Autoreactive T-cells migrate into the bone marrow and augment myelopoiesis which can accelerate inflammation and demyelination in multiple sclerosis
This study revealed that bone marrow, as the primary site of hematopoiesis, has an unrecognized role in MS, promoting intimate interactions between autoreactive T-cells and hematopoietic cells.
