This study demonstrated immunological and other characteristics in individuals experiencing persistent symptoms following COVID-19 vaccination.
Topic
SARS-CoV-2 and the Reactivation of Latent Viruses
The persistence of SARS-CoV-2 antigens, chronic inflammation, reactivation of latent herpes viruses, and decreased cortisol levels were detected in long COVID patients more than one year after acute infection
Biological (immunological, virological and hormonal) features of long COVID syndrome more than one year after acute infection.
Human endogenous retroviruses (HERVs) and immune mediators were differently expressed in children diagnosed with COVID-19, Kawasaki disease, or multisystem inflammatory syndrome in children (MIS-C)
HERV-related genes, HERVs, and immune mediators are differently upregulated in children diagnosed with acute COVID-19, acute or subacute KD, and acute or subacute MIS-C, supporting the role of HERVs in inflammatory diseases and their interaction with the immune system.Â
Among patients hospitalized for psychosis spectrum disorders, circulating levels of human endogenous retroviruses (HERVs)-W envelope proteins and proinflammatory cytokines were increased only in those with a positive anti-SARS-CoV-2 serology
This study demonstrated increased expression of HERV-W ENV proteins and proinflammatory cytokines only in hospitalized patients with psychosis spectrum disorders who were positive for SARS-CoV-2, suggesting a strong link between HERV-W activation, cytokine expression and SARS-CoV-2 infection.
Individuals with post-acute COVID-19 syndrome were found to have circulating levels of human endogenous retrovirus type W (HERV-W) envelope proteins and elevated levels of anti-SARS-CoV-2 IgE antibodies one year after the acute infection
HERV-W ENV protein was expressed in 58% of plasma samples of post-COVID patients, long after the acute SARS-CoV-2 infection was resolved .75% of post-COVID patients had elevated levels of anti-S and anti-N IgE antibodies compared to pre-pandemic controls.
