The carbohydrate PL-M can reduce the viral load in Vero cells. In clinical studies with COVID-19 patients, PL-M treatment resulted in a rapid reduction of viral load and increased viral clearance, with no adverse effects.
Topic
The treatment of COVID-19
Dose-dependent antiviral effect of probenecid in COVID-19
This study showed a dose-dependent antiviral effect of a uricosuric agent probenecid in patients with symptomatic, mild-to-moderate COVID-19.
Histamine receptor H1 binds directly to the N-terminal domain on the SARS-CoV-2 S1 protein and acts as an ACE2-independent receptor for SARS-CoV-2, but also synergistically interacts with ACE2 and facilitates ACE2-dependent viral entry (antihistamines could be a potential treatment for COVID-19)
Histamine receptor H1 acts as an independent receptor for SARS-CoV-2. The antihistamine drugs effectively inhibited the binding of H1R to the S protein and viral infection.
Anti-SARS-CoV-2 properties of natural products derived from plants, honey, and marine sponges
This study analyzes recent research on natural products derived from plants, honey, and marine sponges with properties against the SARS-CoV-2, as well as several potential mechanisms of their action,
21% of vaccinated COVID-19 outpatients treated with nirmatrelvir-ritonavir had a virologic rebound phenomenon and a substantially prolongated shedding of replication-competent viruses
This study demonstrated that virologic rebound was found in 21% of COVID-19 outpatients treated with nirmatrelvir-ritonavir.
