This work highlights different effects of SARS-CoV-2 S protein on both early and late stages of retinal development, and provides insights into the cellular and molecular mechanisms of these effects.
Topic
Long COVID/ Post-COVID-vaccination syndrome & The Structures of the Eye
New-onset or relapse of uveitis within a month after COVID-19 infection or COVID vaccination
These studies found an association between COVID-19 infection or vaccination and newly diagnosed or recurrent uveitis.
Intranasal infection of mice with SARS-CoV-2 led to retinal inflammation and elevated viral titers in the lungs and brain
The prolonged presence of SARS-CoV-2 S protein in ocular tissues (thirty days after the intravitreal injection) resulted in microaneurysms, retinal atrophy, and retinal vein occlusion.
IgG4-related ophthalmic disease after COVID-19 vaccination (case report)
The authors present a patient who developed the ocular manifestation of immunoglobulin (Ig)G4-related disease, referred to as IgG4-related ophthalmic disease (IgG4-ROD), after COVID vaccination.
Reduced corneal innervation and increased density of corneal dendritic cells were found in iIndividuals with long COVID syndrome more than 20 months after acute infection
These results show a decrease in corneal nerve density and branch density, as well as an increase in dendritic cell density in patients with long COVID in comparison to the control group.
The mRNA COVID-19 vaccination increases the risk of retinal vascular occlusion
The overall risk of all forms of retinal vascular occlusion was 2.19 times higher in the vaccinated cohort than in the unvaccinated cohort within two years after COVID-19 vaccination.
