The results showed that the perimenopause (2 years prior and 2 years after the final menstrual period) is a period of increased risk of first-onset major depressive disorder and mania.
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Azithromycin is in vitro superior to other macrolides in the respiratory epithelial barrier enhancement, phospholipid retention, vesicle build-up, and its effect on gene sets related to keratinocyte differentiation
Azithromycin treatment was distinct in terms of enhancement of the epithelial barrier, retention of phospholipids, vesicle build-up, and its effect on gene sets related to keratinocyte differentiation and establishment of skin barrier.
Elevated levels of arthroplasty-relevant metals were found in the blood and cerebrospinal fluid of individuals with arthroplasty implants
This cross-sectional study showed that chronic exposure to arthroplasty implants was associated with increased blood levels of cobalt, chromium, titanium, niobium, and zirconium. Arthroprosthetic cobalt, chromium, titanium, niobium, and zirconium seemed to cross blood-brain barrier and accumulate in CSF.
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Alcohol-associated end-organ complications among adolescents and young adults
Among adolescents and young adults, alcohol-associated pancreatic complications were more frequent than liver-related complications (29% versus 19% respectively), and the most frequent pancreatic complications were acute pancreatitis (92%).
According to a nationwide Swedish study, the use of antidepressants is associated with faster cognitive deterioration in patients with dementia
This nationwide cohort study showed that the current use of antidepressants, in particular SSRIs (i.e., citalopram, sertraline, and escitalopram) and mirtazapine was associated with faster cognitive decline in patients with dementia.
In a 7-year follow-up, 61% of patients diagnosed with type 2 diabetes who had no cardiovascular disease were found to have subclinical left ventricular dysfunction
Type 2 diabetes is an independent risk factor for subclinical left ventricular dysfunction in asymptomatic patients without cardiovascular diseases.
A low level of insulin-like growth factor 1 (IGF-1) in liver cirrhosis is an independent risk factor for decompensation, acute-on-chronic liver failure, and liver-related mortality
Lower levels of IGF-1 were an independent risk factor for further decompensation, acute-on-chronic liver failure and liver-related mortality, highlighting the clinical significance of low IGF-1 in liver cirrhosis.
Radial artery thrombosis occurred in 13% of individuals who underwent coronary angiography via the proximal transradial route
This study investigated the occurrence of radial artery thrombosis following the transradial route of coronary angiography and related risk factors for its occurrence.
Treatment of postpartum constipation using Transcutaneous Tibial Nerve Stimulation (TTNS)
Bilateral TTNS, integrated with traditional physical therapy with diaphragmatic and abdominal exercises, improved constipation symptoms and quality of life in postpartum women.
Sex-specific proteomic profiles of patients with heart failure and reduced ejection fraction
Circulating proteins associated with extracellular matrix organization were overrepresented in women, while those reflecting apoptotic processes were overrepresented in men. The predictive value of circulating proteins measured repeatedly did not differ between sexes, except for endothelin-1 and somatostatin.
The accumulation of nanoparticles in the reproductive organs of female mice
The accumulation of nanoparticles in the female reproductive organs impairs the development of oocytes and can compromise fertility. In addition, cancer treatment with nanomedicines appears to be influenced by the specific biodistribution of nanoparticles in the female reproductive system.
Certain bacterial species in colorectal cancer can resist the toxicity of 5-fluorouracil and reduce drug efficacy
In some patients with colorectal cancer, the intratumoral microbiota possesses the ability to deplete 5-FU, thereby reducing the efficacy of chemotherapeutic agent within the colonized microniches.
The American Heart Association recently defined the cardiovascular-kidney-metabolic syndrome
AHA presidental advisory provides the definition of cardiovascular-kidney-metabolic syndrome syndrome and guides how to better detect, prevent, and manage it.
A possible role of tau protein dysregulation in the pathogenesis of glaucoma
This review article discusses the new perspective of glaucoma as a tau-associated disorder, and analyzes the recent findings on the link between tau protein dysregulation and glaucomatous neurodegeneration.
The risk of cardiac arrhythmias is increased in patients with inflammatory bowel disease (nationwide Swedish cohort study)
The patients with inflammatory bowel disease had an increased long-term risk of developing cardiac arrhythmias, with the exception of bradyarrhythmias
Sex-specific association between depressive symptoms and specific forms of childhood trauma in patients with recent-onset schizophrenia spectrum disorders
This study revealed a gender-specific association between depressive symptoms and specific forms of childhood trauma in patients with recent-onset schizophrenia spectrum disorders. In women, the severity of depressive symptoms was associated with childhood sexual abuse, which was three times as often as in men.
AEF0117, a signaling-specific inhibitor of the type 1 cannabinoid receptor, is a safe and potentially effective treatment for cannabis use disorder
This study showed that AEF0117 reduced the positive subjective effects of cannabis and self-administration of cannabis in individuals with cannabis use disorder in comparison to placebo. It seems that AEF0117 decreases the abuse-related effects of cannabis not affecting normal behavior or activities.
Treatment with ADHD medications is associated with reduced risk of suicide in patients with borderline personality disorder (a nationwide Swedish study)
The use of ADHD medications was associated with a reduced risk of attempted or completed suicide. On the contrary, the use of benzodiazepines was associated with a marked increase in suicide risk.
The neurogenic cardiac injury
This review discusses the main pathophysiological mechanisms of heart-brain interaction leading to the neurogenic cardiac injury.
